Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy

Hypertension is a disease associated to increased plasma levels of angiotensin II (Ang II). Ang II can regulate proliferation, migration, ROS production and hypertrophy of vascular smooth muscle cells (VSMCs). However, the mechanisms by which Ang II can affect VSMCs remain to be fully elucidated. In...

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Bibliographic Details
Main Authors: David Mondaca-Ruff, Jaime A. Riquelme, Clara Quiroga, Ignacio Norambuena-Soto, Fernanda Sanhueza-Olivares, Paulina Villar-Fincheira, Tomás Hernández-Díaz, Nicole Cancino-Arenas, Alejandra San Martin, Lorena García, Sergio Lavandero, Mario Chiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
angiotensin II
VSMC
autophagy
hypertrophy
AT1R
ROCK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01553/full

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