Neonatal Graves' Disease with Maternal Hypothyroidism
Neonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes a gamut of liver and systemic diseases. We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2017-07-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1606365 |
| _version_ | 1818254863931277312 |
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| author | Gangaram Akangire Alain Cuna Charisse Lachica Ryan Fischer Sripriya Raman Venkatesh Sampath |
| author_facet | Gangaram Akangire Alain Cuna Charisse Lachica Ryan Fischer Sripriya Raman Venkatesh Sampath |
| author_sort | Gangaram Akangire |
| collection | DOAJ |
| description | Neonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes a gamut of liver and systemic diseases. We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Thyroid function improved after 8 weeks of treatment with full recovery of thyroid function, disappearance of thyroid-stimulating antibodies, and resolution of failure to thrive and conjugated hyperbilirubinemia. This case provides several clinical vignettes as it is a rare, severe, presentation of an uncommon neonatal disease, signs, symptoms, and clinical history presented a diagnostic challenge for neonatologists and endocrinologists, normal newborn screen was misleading, and yet timely treatment led to a full recovery. |
| first_indexed | 2024-12-12T17:02:44Z |
| format | Article |
| id | doaj.art-27a184a4b593449c954bac7eaf5d62ea |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-12T17:02:44Z |
| publishDate | 2017-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-27a184a4b593449c954bac7eaf5d62ea2022-12-22T00:18:05ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052017-07-010703e181e18410.1055/s-0037-1606365Neonatal Graves' Disease with Maternal HypothyroidismGangaram Akangire0Alain Cuna1Charisse Lachica2Ryan Fischer3Sripriya Raman4Venkatesh Sampath5Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MissouriDepartment of Pediatrics, Children's Mercy Kansas City, Kansas City, MissouriDepartment of Pediatrics, Children's Mercy Kansas City, Kansas City, MissouriDepartment of Pediatrics, Children's Mercy Kansas City, Kansas City, MissouriDepartment of Pediatrics, Children's Mercy Kansas City, Kansas City, MissouriDepartment of Pediatrics, Children's Mercy Kansas City, Kansas City, MissouriNeonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes a gamut of liver and systemic diseases. We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Thyroid function improved after 8 weeks of treatment with full recovery of thyroid function, disappearance of thyroid-stimulating antibodies, and resolution of failure to thrive and conjugated hyperbilirubinemia. This case provides several clinical vignettes as it is a rare, severe, presentation of an uncommon neonatal disease, signs, symptoms, and clinical history presented a diagnostic challenge for neonatologists and endocrinologists, normal newborn screen was misleading, and yet timely treatment led to a full recovery.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1606365cholestasisfailure to thrivehyperthyroidismgraves' disease |
| spellingShingle | Gangaram Akangire Alain Cuna Charisse Lachica Ryan Fischer Sripriya Raman Venkatesh Sampath Neonatal Graves' Disease with Maternal Hypothyroidism American Journal of Perinatology Reports cholestasis failure to thrive hyperthyroidism graves' disease |
| title | Neonatal Graves' Disease with Maternal Hypothyroidism |
| title_full | Neonatal Graves' Disease with Maternal Hypothyroidism |
| title_fullStr | Neonatal Graves' Disease with Maternal Hypothyroidism |
| title_full_unstemmed | Neonatal Graves' Disease with Maternal Hypothyroidism |
| title_short | Neonatal Graves' Disease with Maternal Hypothyroidism |
| title_sort | neonatal graves disease with maternal hypothyroidism |
| topic | cholestasis failure to thrive hyperthyroidism graves' disease |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1606365 |
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