Designing Paper-Based Immunoassays for Biomedical Applications
Paper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/19/3/554 |
| _version_ | 1811306854744064000 |
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| author | Delyan R. Hristov Cristina Rodriguez-Quijada Jose Gomez-Marquez Kimberly Hamad-Schifferli |
| author_facet | Delyan R. Hristov Cristina Rodriguez-Quijada Jose Gomez-Marquez Kimberly Hamad-Schifferli |
| author_sort | Delyan R. Hristov |
| collection | DOAJ |
| description | Paper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost and simplicity of operation. This review is aimed at examining the fundamentals of the technology, as well as different implementations of paper-based assays and discuss novel strategies for improving their sensitivity, performance, or enabling new capabilities. These innovations can be categorized into using unique nanoparticle materials and structures for detection via different techniques, novel biological species for recognizing biomarkers, or innovative device design and/or architecture. |
| first_indexed | 2024-04-13T08:52:59Z |
| format | Article |
| id | doaj.art-27a1bc9fba614a9291fb0861873e9084 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T08:52:59Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-27a1bc9fba614a9291fb0861873e90842022-12-22T02:53:23ZengMDPI AGSensors1424-82202019-01-0119355410.3390/s19030554s19030554Designing Paper-Based Immunoassays for Biomedical ApplicationsDelyan R. Hristov0Cristina Rodriguez-Quijada1Jose Gomez-Marquez2Kimberly Hamad-Schifferli3Department of Engineering, University of Massachusetts, Boston, MA 02125, USADepartment of Engineering, University of Massachusetts, Boston, MA 02125, USALittle Devices Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Engineering, University of Massachusetts, Boston, MA 02125, USAPaper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost and simplicity of operation. This review is aimed at examining the fundamentals of the technology, as well as different implementations of paper-based assays and discuss novel strategies for improving their sensitivity, performance, or enabling new capabilities. These innovations can be categorized into using unique nanoparticle materials and structures for detection via different techniques, novel biological species for recognizing biomarkers, or innovative device design and/or architecture.https://www.mdpi.com/1424-8220/19/3/554paper-based immunoassayslateral flow assaybiological sensorsdipstick assayrapid diagnostics |
| spellingShingle | Delyan R. Hristov Cristina Rodriguez-Quijada Jose Gomez-Marquez Kimberly Hamad-Schifferli Designing Paper-Based Immunoassays for Biomedical Applications Sensors paper-based immunoassays lateral flow assay biological sensors dipstick assay rapid diagnostics |
| title | Designing Paper-Based Immunoassays for Biomedical Applications |
| title_full | Designing Paper-Based Immunoassays for Biomedical Applications |
| title_fullStr | Designing Paper-Based Immunoassays for Biomedical Applications |
| title_full_unstemmed | Designing Paper-Based Immunoassays for Biomedical Applications |
| title_short | Designing Paper-Based Immunoassays for Biomedical Applications |
| title_sort | designing paper based immunoassays for biomedical applications |
| topic | paper-based immunoassays lateral flow assay biological sensors dipstick assay rapid diagnostics |
| url | https://www.mdpi.com/1424-8220/19/3/554 |
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