Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model
In this study, PLLA-based sirolimus-eluting polymer scaffolds and permanent bare-metal stents (316L) were implanted interventionally into both common carotid arteries (CCA) of 6 female pigs via the left common iliac artery (8F-sheath). The pigs were administered dual antiplatelet drugs peroral start...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-09-01
|
| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2018-0111 |
| _version_ | 1811194140361228288 |
|---|---|
| author | Kischkel Sabine Bünger Carsten M. Püschel Anja Schareck Wolfgang Schmitz Klaus-Peter Grabow Niels |
| author_facet | Kischkel Sabine Bünger Carsten M. Püschel Anja Schareck Wolfgang Schmitz Klaus-Peter Grabow Niels |
| author_sort | Kischkel Sabine |
| collection | DOAJ |
| description | In this study, PLLA-based sirolimus-eluting polymer scaffolds and permanent bare-metal stents (316L) were implanted interventionally into both common carotid arteries (CCA) of 6 female pigs via the left common iliac artery (8F-sheath). The pigs were administered dual antiplatelet drugs peroral starting 3 days before the procedure until the end of the study. Stented CCA segments were explanted after 12 weeks, and processed for quantitative histomorphometry, and estimation of vascular inflammation and injury scores. SIR/polymer scaffolds showed a decreased residual lumen area and higher restenosis after 12 weeks (4.45 ± 2.23 mm² and 61.68 ± 22.39%) as compared to the 316L reference stent (16.53 ± 1.23 mm² and 6.65 ± 1.30%). After 12 weeks, inflammation score and vascular injury score were higher in the SIR/polymer group (1.90 ± 1.15 and 1.26 ± 0.87) compared to the 316L group (0.57 ± 0.37 and 0.83 ± 0.34). |
| first_indexed | 2024-04-12T00:20:54Z |
| format | Article |
| id | doaj.art-27a255025ed042d08deaf63523dcd9b8 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-12T00:20:54Z |
| publishDate | 2018-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-27a255025ed042d08deaf63523dcd9b82022-12-22T03:55:43ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042018-09-014146546710.1515/cdbme-2018-0111cdbme-2018-0111Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine modelKischkel Sabine0Bünger Carsten M.1Püschel Anja2Schareck Wolfgang3Schmitz Klaus-Peter4Grabow Niels5Department of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center,Rostock, GermanyDepartment of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center,Rostock, GermanyDepartment of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center,Rostock, GermanyDepartment of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center,Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center,Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center,Rostock, GermanyIn this study, PLLA-based sirolimus-eluting polymer scaffolds and permanent bare-metal stents (316L) were implanted interventionally into both common carotid arteries (CCA) of 6 female pigs via the left common iliac artery (8F-sheath). The pigs were administered dual antiplatelet drugs peroral starting 3 days before the procedure until the end of the study. Stented CCA segments were explanted after 12 weeks, and processed for quantitative histomorphometry, and estimation of vascular inflammation and injury scores. SIR/polymer scaffolds showed a decreased residual lumen area and higher restenosis after 12 weeks (4.45 ± 2.23 mm² and 61.68 ± 22.39%) as compared to the 316L reference stent (16.53 ± 1.23 mm² and 6.65 ± 1.30%). After 12 weeks, inflammation score and vascular injury score were higher in the SIR/polymer group (1.90 ± 1.15 and 1.26 ± 0.87) compared to the 316L group (0.57 ± 0.37 and 0.83 ± 0.34).https://doi.org/10.1515/cdbme-2018-0111biodegradable polymeric scaffolddrugexperimental pig studycarotid artery stenting |
| spellingShingle | Kischkel Sabine Bünger Carsten M. Püschel Anja Schareck Wolfgang Schmitz Klaus-Peter Grabow Niels Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model Current Directions in Biomedical Engineering biodegradable polymeric scaffold drug experimental pig study carotid artery stenting |
| title | Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model |
| title_full | Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model |
| title_fullStr | Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model |
| title_full_unstemmed | Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model |
| title_short | Vascular response towards biodegradable sirolimus-eluting polymeric scaffolds in the porcine model |
| title_sort | vascular response towards biodegradable sirolimus eluting polymeric scaffolds in the porcine model |
| topic | biodegradable polymeric scaffold drug experimental pig study carotid artery stenting |
| url | https://doi.org/10.1515/cdbme-2018-0111 |
| work_keys_str_mv | AT kischkelsabine vascularresponsetowardsbiodegradablesirolimuselutingpolymericscaffoldsintheporcinemodel AT bungercarstenm vascularresponsetowardsbiodegradablesirolimuselutingpolymericscaffoldsintheporcinemodel AT puschelanja vascularresponsetowardsbiodegradablesirolimuselutingpolymericscaffoldsintheporcinemodel AT schareckwolfgang vascularresponsetowardsbiodegradablesirolimuselutingpolymericscaffoldsintheporcinemodel AT schmitzklauspeter vascularresponsetowardsbiodegradablesirolimuselutingpolymericscaffoldsintheporcinemodel AT grabowniels vascularresponsetowardsbiodegradablesirolimuselutingpolymericscaffoldsintheporcinemodel |