Concentration-dependent alpha1-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate

Concentration-dependent alpha1-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate

Introduction: Mirabegron is available for treatment of storage symptoms in overactive bladder, which may be improved by β3-adrenoceptor-induced bladder smooth muscle relaxation. In addition to storage symptoms, lower urinary tract symptoms in men include obstructive symptoms attributed to benign pro...

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Bibliographic Details
Main Authors:	Ru Huang, Yuhan Liu, Anna Ciotkowska, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G. Stief, Martin Hennenberg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Pharmacology
Subjects:	mirabegron lower urinary tract symptoms (LUTS) benign prostatic hyperplasia (BPH) obstructive symptoms bladder outlet obstruction (BOO) prostate smooth muscle contraction
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.666047/full

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