Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood
IntroductionTo investigate immunogenic changes after percutaneous microwave ablation (MWA) in pulmonary malignancies.MethodsTwenty-two consecutive patients with pulmonary malignancies who underwent percutaneous lung tumor MWA were prospectively enrolled in this study. Peripheral blood samples were c...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069192/full |
| _version_ | 1811205340200435712 |
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| author | Liang Zhang Mingming Zhang Jun Wang Yang Li Taijie Wang Jianguo Xia Bo Feng Jialin Shen |
| author_facet | Liang Zhang Mingming Zhang Jun Wang Yang Li Taijie Wang Jianguo Xia Bo Feng Jialin Shen |
| author_sort | Liang Zhang |
| collection | DOAJ |
| description | IntroductionTo investigate immunogenic changes after percutaneous microwave ablation (MWA) in pulmonary malignancies.MethodsTwenty-two consecutive patients with pulmonary malignancies who underwent percutaneous lung tumor MWA were prospectively enrolled in this study. Peripheral blood samples were collected on the day before (D0) and one month (M1) after MWA. Changes in immune cell subsets (CD3+, CD4+, and CD8+ T cells, and B, natural killer, regulatory T (Treg), and CD3-CD20+ cells) and cytokines (interleukin [IL]-2, 4, 6, 10, 17A, tumor necrosis factor [TNF]-α, and interferon-γ) were noted and compared. Progression-free survival (PFS) and potentially related factors were analyzed.ResultsThe proportion of CD8+ T cells increased from 22.95 ± 7.38% (D0) to 25.95 ± 9.16% (M1) (p = 0.031). The proportion of Treg cells decreased from 10.82 ± 4.52% (D0) to 8.77 ± 2.05% (M1) (p = 0.049). The IL-2 concentration was also decreased from 1.58 ± 0.46 pg/mL (D0) to 1.26 ± 0.60 pg/mL (M1) (p = 0.028). The reduction in Treg cells predicted PFS independently of clinical prognostic features in multivariate analysis (hazard ratio = 4.97, 95% confidence interval: 1.32–18.66, p = 0.018). A reduction in the proportion of Treg cells was observed in 15 patients (68.2%) and the average of the reduction was 2.05 ± 4.60%. Those patients with a reduction in the proportion of Treg cells that was more than average showed a significantly longer median PFS time than those with a reduction that was less than average (16 months vs. 8.5 months, p = 0.025).DiscussionPercutaneous MWA of pulmonary malignancies leads to immunogenic changes. The reduction in the proportion of Treg cells was independently associated with PFS. |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T03:29:18Z |
| publishDate | 2022-12-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-27a3cdd8e6fb483ab3620819715c6ff22022-12-22T03:49:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10691921069192Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral bloodLiang Zhang0Mingming Zhang1Jun Wang2Yang Li3Taijie Wang4Jianguo Xia5Bo Feng6Jialin Shen7Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, ChinaSchool of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, ChinaDepartment of Radiology, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, ChinaDepartment of Radiology, People’s Hospital of Qintong, Taizhou, Jiangsu, ChinaDepartment of Ultrasound, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, ChinaDepartment of Interventional Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, ChinaIntroductionTo investigate immunogenic changes after percutaneous microwave ablation (MWA) in pulmonary malignancies.MethodsTwenty-two consecutive patients with pulmonary malignancies who underwent percutaneous lung tumor MWA were prospectively enrolled in this study. Peripheral blood samples were collected on the day before (D0) and one month (M1) after MWA. Changes in immune cell subsets (CD3+, CD4+, and CD8+ T cells, and B, natural killer, regulatory T (Treg), and CD3-CD20+ cells) and cytokines (interleukin [IL]-2, 4, 6, 10, 17A, tumor necrosis factor [TNF]-α, and interferon-γ) were noted and compared. Progression-free survival (PFS) and potentially related factors were analyzed.ResultsThe proportion of CD8+ T cells increased from 22.95 ± 7.38% (D0) to 25.95 ± 9.16% (M1) (p = 0.031). The proportion of Treg cells decreased from 10.82 ± 4.52% (D0) to 8.77 ± 2.05% (M1) (p = 0.049). The IL-2 concentration was also decreased from 1.58 ± 0.46 pg/mL (D0) to 1.26 ± 0.60 pg/mL (M1) (p = 0.028). The reduction in Treg cells predicted PFS independently of clinical prognostic features in multivariate analysis (hazard ratio = 4.97, 95% confidence interval: 1.32–18.66, p = 0.018). A reduction in the proportion of Treg cells was observed in 15 patients (68.2%) and the average of the reduction was 2.05 ± 4.60%. Those patients with a reduction in the proportion of Treg cells that was more than average showed a significantly longer median PFS time than those with a reduction that was less than average (16 months vs. 8.5 months, p = 0.025).DiscussionPercutaneous MWA of pulmonary malignancies leads to immunogenic changes. The reduction in the proportion of Treg cells was independently associated with PFS.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069192/fullCD8+ T cellIL-2percutaneous microwave ablationpulmonary malignanciesregulatory T cellsimmune system |
| spellingShingle | Liang Zhang Mingming Zhang Jun Wang Yang Li Taijie Wang Jianguo Xia Bo Feng Jialin Shen Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood Frontiers in Immunology CD8+ T cell IL-2 percutaneous microwave ablation pulmonary malignancies regulatory T cells immune system |
| title | Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood |
| title_full | Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood |
| title_fullStr | Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood |
| title_full_unstemmed | Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood |
| title_short | Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood |
| title_sort | immunogenic change after percutaneous microwave ablation in pulmonary malignancies variation in immune cell subsets and cytokines in peripheral blood |
| topic | CD8+ T cell IL-2 percutaneous microwave ablation pulmonary malignancies regulatory T cells immune system |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069192/full |
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