Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D<sub>2</sub> Receptor
SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine D<sub>2</sub> receptor (D<sub>2</sub>R), however, the binding mode and allosteric mechanism of action of this ligand remain incompletely understood. SB269,652 comprises an orthosteri...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/1/22 |