HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice
The effects of (<i>E</i>)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HMC) on hyperglycemia and dyslipidemia were investigated in diabetic mice. Mice were separated into three groups: db/db, rosiglitazone and HMC. Blood glucose or glycosylated hemoglobin values in HMC-treated m...
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MDPI AG
2022-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/9/1951 |
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| author | Jae Eun Park Jaemin Son Youngwan Seo Ji Sook Han |
| author_facet | Jae Eun Park Jaemin Son Youngwan Seo Ji Sook Han |
| author_sort | Jae Eun Park |
| collection | DOAJ |
| description | The effects of (<i>E</i>)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HMC) on hyperglycemia and dyslipidemia were investigated in diabetic mice. Mice were separated into three groups: db/db, rosiglitazone and HMC. Blood glucose or glycosylated hemoglobin values in HMC-treated mice were significantly lower compared to db/db mice. Total cholesterol, LDL-cholesterol, and triglyceride values were lower, and HDL-C levels were higher, in the HMC group compared to the diabetic and rosiglitazone groups. HMC markedly increased IRS-1<sup>Tyr612</sup>, Akt<sup>Ser473</sup> and PI3K levels and plasma membrane GLUT4 levels in skeletal muscle, suggesting improved insulin resistance. HMC also significantly stimulated AMPK<sup>Thr172</sup> and PPARα in the liver, and ameliorated dyslipidemia by inhibiting SREBP-1c and FAS. Consequently, HMC reduced hyperglycemia by improving the expression of insulin-resistance-related genes and improved dyslipidemia by regulating fatty acid synthase and oxidation-related genes in db/db mice. Therefore, HMC could ameliorate hyperglycemia and dyslipidemia in type 2 diabetic mice. |
| first_indexed | 2024-03-10T03:48:32Z |
| format | Article |
| id | doaj.art-27a6c6ca982245c488b7c512ef22892b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:48:32Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-27a6c6ca982245c488b7c512ef22892b2023-11-23T09:00:52ZengMDPI AGNutrients2072-66432022-05-01149195110.3390/nu14091951HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic MiceJae Eun Park0Jaemin Son1Youngwan Seo2Ji Sook Han3Department of Food Science and Nutrition, Pusan National University, Busan 46241, KoreaDivision of Marine Bioscience, Ocean Science & Technology School, Korea Maritime and Ocean University, Busan 49112, KoreaDivision of Marine Bioscience, Ocean Science & Technology School, Korea Maritime and Ocean University, Busan 49112, KoreaDepartment of Food Science and Nutrition, Pusan National University, Busan 46241, KoreaThe effects of (<i>E</i>)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HMC) on hyperglycemia and dyslipidemia were investigated in diabetic mice. Mice were separated into three groups: db/db, rosiglitazone and HMC. Blood glucose or glycosylated hemoglobin values in HMC-treated mice were significantly lower compared to db/db mice. Total cholesterol, LDL-cholesterol, and triglyceride values were lower, and HDL-C levels were higher, in the HMC group compared to the diabetic and rosiglitazone groups. HMC markedly increased IRS-1<sup>Tyr612</sup>, Akt<sup>Ser473</sup> and PI3K levels and plasma membrane GLUT4 levels in skeletal muscle, suggesting improved insulin resistance. HMC also significantly stimulated AMPK<sup>Thr172</sup> and PPARα in the liver, and ameliorated dyslipidemia by inhibiting SREBP-1c and FAS. Consequently, HMC reduced hyperglycemia by improving the expression of insulin-resistance-related genes and improved dyslipidemia by regulating fatty acid synthase and oxidation-related genes in db/db mice. Therefore, HMC could ameliorate hyperglycemia and dyslipidemia in type 2 diabetic mice.https://www.mdpi.com/2072-6643/14/9/1951HM-chromanonehigh blood glucoseAMPKtype 2 diabetesdb/db mice |
| spellingShingle | Jae Eun Park Jaemin Son Youngwan Seo Ji Sook Han HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice Nutrients HM-chromanone high blood glucose AMPK type 2 diabetes db/db mice |
| title | HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice |
| title_full | HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice |
| title_fullStr | HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice |
| title_full_unstemmed | HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice |
| title_short | HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice |
| title_sort | hm chromanone ameliorates hyperglycemia and dyslipidemia in type 2 diabetic mice |
| topic | HM-chromanone high blood glucose AMPK type 2 diabetes db/db mice |
| url | https://www.mdpi.com/2072-6643/14/9/1951 |
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