A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis.
BACKGROUND:Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC6355028?pdf=render |
| _version_ | 1818142291855933440 |
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| author | Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa |
| author_facet | Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa |
| author_sort | Shakirat A Adetunji |
| collection | DOAJ |
| description | BACKGROUND:Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review the literature and perform a meta-analysis to estimate the global prevalence of osteoarticular brucellosis (OAB). METHODOLOGY:Major bibliographic databases were searched using keywords and suitable combinations. All studies reporting the incidence and clinical manifestations of osteoarticular brucellosis in humans, and demonstrated by two or more diagnostic methods (bacteriological, molecular, serological, and/or radiographic) were included. Random model was used, and statistical significance was set at 0.05. PRINCIPAL FINDINGS:A total of 56 studies met the inclusion criteria and were included in the systematic review and meta-analysis. There was an evidence of geographical variation in the prevalence of osteoarticular disease with estimates ranging from 27% in low-risk regions to 36% in high-risk regions. However, the difference was not significant. Thus, brucellosis patients have at least a 27% chance of developing osteoarticular disease. CONCLUSIONS:The prevalence of OAB is not dependent on the endemicity of brucellosis in a particular region. Hence, further research should investigate the potential mechanisms of OAB, as well as the influence of age, gender, and other socioeconomic factor variations in its global prevalence, as this may provide insight into associated exposure risks and management of the disease. |
| first_indexed | 2024-12-11T11:13:27Z |
| format | Article |
| id | doaj.art-27a6d2982c384a5789d4e580ca5e5ed7 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-11T11:13:27Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-27a6d2982c384a5789d4e580ca5e5ed72022-12-22T01:09:25ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352019-01-01131e000711210.1371/journal.pntd.0007112A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis.Shakirat A AdetunjiGilbert RamirezMargaret J FosterAngela M Arenas-GamboaBACKGROUND:Infection of bones and joints remains one of the most commonly described complications of brucellosis in humans and is predominantly reported in all ages and sexes in high-risk regions, such as the Middle East, Asia, South and Central America, and Africa. We aimed to systematically review the literature and perform a meta-analysis to estimate the global prevalence of osteoarticular brucellosis (OAB). METHODOLOGY:Major bibliographic databases were searched using keywords and suitable combinations. All studies reporting the incidence and clinical manifestations of osteoarticular brucellosis in humans, and demonstrated by two or more diagnostic methods (bacteriological, molecular, serological, and/or radiographic) were included. Random model was used, and statistical significance was set at 0.05. PRINCIPAL FINDINGS:A total of 56 studies met the inclusion criteria and were included in the systematic review and meta-analysis. There was an evidence of geographical variation in the prevalence of osteoarticular disease with estimates ranging from 27% in low-risk regions to 36% in high-risk regions. However, the difference was not significant. Thus, brucellosis patients have at least a 27% chance of developing osteoarticular disease. CONCLUSIONS:The prevalence of OAB is not dependent on the endemicity of brucellosis in a particular region. Hence, further research should investigate the potential mechanisms of OAB, as well as the influence of age, gender, and other socioeconomic factor variations in its global prevalence, as this may provide insight into associated exposure risks and management of the disease.http://europepmc.org/articles/PMC6355028?pdf=render |
| spellingShingle | Shakirat A Adetunji Gilbert Ramirez Margaret J Foster Angela M Arenas-Gamboa A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. PLoS Neglected Tropical Diseases |
| title | A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
| title_full | A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
| title_fullStr | A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
| title_full_unstemmed | A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
| title_short | A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. |
| title_sort | systematic review and meta analysis of the prevalence of osteoarticular brucellosis |
| url | http://europepmc.org/articles/PMC6355028?pdf=render |
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