Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study
Low grade meningiomas have better prognosis than high grade meningiomas. The aim of this study was to measure apparent diffusion coefficient (ADC) histogram analysis parameters in different meningiomas in a large multicenter sample and to analyze the possibility of several parameters for predicting...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-10-01
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| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523318302195 |
| _version_ | 1828794654811750400 |
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| author | Alexey Surov Daniel T Ginat Tchoyoson Lim Teresa Cabada Ozdil Baskan Stefan Schob Hans Jonas Meyer Georg Alexander Gihr Diana Horvath-Rizea Gordian Hamerla Karl Titus Hoffmann Andreas Wienke |
| author_facet | Alexey Surov Daniel T Ginat Tchoyoson Lim Teresa Cabada Ozdil Baskan Stefan Schob Hans Jonas Meyer Georg Alexander Gihr Diana Horvath-Rizea Gordian Hamerla Karl Titus Hoffmann Andreas Wienke |
| author_sort | Alexey Surov |
| collection | DOAJ |
| description | Low grade meningiomas have better prognosis than high grade meningiomas. The aim of this study was to measure apparent diffusion coefficient (ADC) histogram analysis parameters in different meningiomas in a large multicenter sample and to analyze the possibility of several parameters for predicting tumor grade and proliferation potential. Overall, 148 meningiomas from 7 institutions were evaluated in this retrospective study. Grade 1 lesions were diagnosed in 101 (68.2%) cases, grade 2 in 41 (27.7%) patients, and grade 3 in 6 (4.1%) patients. All tumors were investigated by MRI (1.5 T scanner) by using diffusion weighted imaging (b values of 0 and 1000 s/mm2). For every lesion, the following parameters were calculated: mean ADC, maximum ADC, minimum ADC, median ADC, mode ADC, ADC percentiles P10, P25, P75, P90, kurtosis, skewness, and entropy. The comparison of ADC values was performed by Mann–Whitney-U test. Correlation between different ADC parameters and KI 67 was calculated by Spearman's rank correlation coefficient. Grade 2/3 meningiomas showed statistically significant lower ADC histogram analysis parameters in comparison to grade 1 tumors, especially ADC median. A threshold value of 0.82 for ADC median to predict tumor grade was estimated (sensitivity = 82.2%, specificity = 63.8%, accuracy = 76.4%, positive and negative predictive values were 83% and 62.5%, respectively).All ADC parameters except maximum ADC showed weak significant correlations with KI 67, especially ADC P25 (P = −.340, P = .0001). |
| first_indexed | 2024-12-12T03:50:04Z |
| format | Article |
| id | doaj.art-27a7afbd66754bcebb9550bc8c7017a4 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-12T03:50:04Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-27a7afbd66754bcebb9550bc8c7017a42022-12-22T00:39:24ZengElsevierTranslational Oncology1936-52332018-10-0111510741079Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter StudyAlexey Surov0Daniel T Ginat1Tchoyoson Lim2Teresa Cabada3Ozdil Baskan4Stefan Schob5Hans Jonas Meyer6Georg Alexander Gihr7Diana Horvath-Rizea8Gordian Hamerla9Karl Titus Hoffmann10Andreas Wienke11Department of Radiology, Martin-Luther-University Halle-Wittenberg, Germany; Department of Diagnostic and Interventional Radiology, University of Leipzig, Germany; Address all correspondence to: Professor MD Alexey Surov, Department of Diagnostic and Interventional Radiology, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.University of Chicago, Pritzker School of Medicine, Chicago, IL, USADepartment of Neuroradiology, National Neuroscience Institute, SingaporeServicio de Radiologia, Hospital de Navarra, Pamplona, SpainDepartment of Radiology, School of Medicine, Istanbul Medipol University, Istanbul, TurkeyDepartment of Neuroradiology, University of LeipzigDepartment of Diagnostic and Interventional Radiology, University of Leipzig, GermanyClinic for Neuroradiology, Katharinenhospital Stuttgart, Stuttgart, GermanyClinic for Neuroradiology, Katharinenhospital Stuttgart, Stuttgart, GermanyDepartment of Neuroradiology, University of LeipzigDepartment of Neuroradiology, University of LeipzigInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther University Halle-Wittenberg, Halle, GermanyLow grade meningiomas have better prognosis than high grade meningiomas. The aim of this study was to measure apparent diffusion coefficient (ADC) histogram analysis parameters in different meningiomas in a large multicenter sample and to analyze the possibility of several parameters for predicting tumor grade and proliferation potential. Overall, 148 meningiomas from 7 institutions were evaluated in this retrospective study. Grade 1 lesions were diagnosed in 101 (68.2%) cases, grade 2 in 41 (27.7%) patients, and grade 3 in 6 (4.1%) patients. All tumors were investigated by MRI (1.5 T scanner) by using diffusion weighted imaging (b values of 0 and 1000 s/mm2). For every lesion, the following parameters were calculated: mean ADC, maximum ADC, minimum ADC, median ADC, mode ADC, ADC percentiles P10, P25, P75, P90, kurtosis, skewness, and entropy. The comparison of ADC values was performed by Mann–Whitney-U test. Correlation between different ADC parameters and KI 67 was calculated by Spearman's rank correlation coefficient. Grade 2/3 meningiomas showed statistically significant lower ADC histogram analysis parameters in comparison to grade 1 tumors, especially ADC median. A threshold value of 0.82 for ADC median to predict tumor grade was estimated (sensitivity = 82.2%, specificity = 63.8%, accuracy = 76.4%, positive and negative predictive values were 83% and 62.5%, respectively).All ADC parameters except maximum ADC showed weak significant correlations with KI 67, especially ADC P25 (P = −.340, P = .0001).http://www.sciencedirect.com/science/article/pii/S1936523318302195 |
| spellingShingle | Alexey Surov Daniel T Ginat Tchoyoson Lim Teresa Cabada Ozdil Baskan Stefan Schob Hans Jonas Meyer Georg Alexander Gihr Diana Horvath-Rizea Gordian Hamerla Karl Titus Hoffmann Andreas Wienke Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study Translational Oncology |
| title | Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study |
| title_full | Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study |
| title_fullStr | Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study |
| title_full_unstemmed | Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study |
| title_short | Histogram Analysis Parameters Apparent Diffusion Coefficient for Distinguishing High and Low-Grade Meningiomas: A Multicenter Study |
| title_sort | histogram analysis parameters apparent diffusion coefficient for distinguishing high and low grade meningiomas a multicenter study |
| url | http://www.sciencedirect.com/science/article/pii/S1936523318302195 |
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