Bullous pemphigoid induced by Hijama therapy (cupping)

Bullous pemphigoid (BP) is described as a subepidermal blistering disorder, which is commonly reported among the elderly, particularly those older than 60 years of age. In this report, we present the case of a 41-year-old female patient with BP lesions that were initially detected at the site of Hij...

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Main Authors: Arghavan Azizpour, Maryam Nasimi, Safoura Shakoei, Fariba Mohammadi, Arsalan Azizpour
Format: Article
Language:English
Published: Mattioli1885 2018-07-01
Series:Dermatology Practical & Conceptual
Subjects:
Online Access:http://dpcj.org/index.php/dpc/article/view/424
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author Arghavan Azizpour
Maryam Nasimi
Safoura Shakoei
Fariba Mohammadi
Arsalan Azizpour
author_facet Arghavan Azizpour
Maryam Nasimi
Safoura Shakoei
Fariba Mohammadi
Arsalan Azizpour
author_sort Arghavan Azizpour
collection DOAJ
description Bullous pemphigoid (BP) is described as a subepidermal blistering disorder, which is commonly reported among the elderly, particularly those older than 60 years of age. In this report, we present the case of a 41-year-old female patient with BP lesions that were initially detected at the site of Hijama therapy with a subsequent generalized spread. Punch biopsy from the lesions and perilesional direct immunofluorescence (DIF) demonstrated features of BP. The anti-BP180 level was 178 RU/mL, and the anti-BP230 level was negative. BP antigens at the site of Hijama caused an antibody response, which led to widespread blistering over the trunk due to epitope spreading. In a comprehensive review of the literature, a total of 22 BP patients with lesions due to physical trauma were studied, and clinical, immunological, and epidemiological information was gathered. This article is the first report on the occurrence of BP induced by Hijama therapy.
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spelling doaj.art-27a8f9b6bc4e46129d218cc4d01523792022-12-21T23:19:34ZengMattioli1885Dermatology Practical & Conceptual2160-93812018-07-0183Bullous pemphigoid induced by Hijama therapy (cupping)Arghavan Azizpour0Maryam Nasimi1Safoura Shakoei2Fariba Mohammadi3Arsalan Azizpour4Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences (TUMS), Tehran, IranAutoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Dermatology, imam Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, IranAutoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences (TUMS), Tehran, IranTehran University of Medical Sciences (TUMS), Tehran, IranBullous pemphigoid (BP) is described as a subepidermal blistering disorder, which is commonly reported among the elderly, particularly those older than 60 years of age. In this report, we present the case of a 41-year-old female patient with BP lesions that were initially detected at the site of Hijama therapy with a subsequent generalized spread. Punch biopsy from the lesions and perilesional direct immunofluorescence (DIF) demonstrated features of BP. The anti-BP180 level was 178 RU/mL, and the anti-BP230 level was negative. BP antigens at the site of Hijama caused an antibody response, which led to widespread blistering over the trunk due to epitope spreading. In a comprehensive review of the literature, a total of 22 BP patients with lesions due to physical trauma were studied, and clinical, immunological, and epidemiological information was gathered. This article is the first report on the occurrence of BP induced by Hijama therapy.http://dpcj.org/index.php/dpc/article/view/424bullous pemphigoidHijamatrigger factortrauma
spellingShingle Arghavan Azizpour
Maryam Nasimi
Safoura Shakoei
Fariba Mohammadi
Arsalan Azizpour
Bullous pemphigoid induced by Hijama therapy (cupping)
Dermatology Practical & Conceptual
bullous pemphigoid
Hijama
trigger factor
trauma
title Bullous pemphigoid induced by Hijama therapy (cupping)
title_full Bullous pemphigoid induced by Hijama therapy (cupping)
title_fullStr Bullous pemphigoid induced by Hijama therapy (cupping)
title_full_unstemmed Bullous pemphigoid induced by Hijama therapy (cupping)
title_short Bullous pemphigoid induced by Hijama therapy (cupping)
title_sort bullous pemphigoid induced by hijama therapy cupping
topic bullous pemphigoid
Hijama
trigger factor
trauma
url http://dpcj.org/index.php/dpc/article/view/424
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