The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review)
The aim. To analyze scientific researches on studying the biomarkers of fibrosis based on a review of the most recent publications for the possibility to predict electrical myocardial instability development. In total, 101 sources of literature related to the role of fibrosis biomarkers in the pa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2021-04-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/205757/228130 |
| _version_ | 1818741358410596352 |
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| author | V. P. Ivanov Yu. Yu. Shushkovska I. V. Danylchuk V. Р. Shcherbak T. Yu. Tsybrii |
| author_facet | V. P. Ivanov Yu. Yu. Shushkovska I. V. Danylchuk V. Р. Shcherbak T. Yu. Tsybrii |
| author_sort | V. P. Ivanov |
| collection | DOAJ |
| description | The aim. To analyze scientific researches on studying the biomarkers of fibrosis based on a review of the most recent publications for the possibility to predict electrical myocardial instability development.
In total, 101 sources of literature related to the role of fibrosis biomarkers in the past 5 years were analyzed. The review of the literature has shown that myocardial fibrosis іs considered to be an arrhythmogenic substrate for ventricular arrhythmias, as it provides structural and functional disorders of the cardiac electrical activity. Markers of fibrosis, which are measured in cardiac pathology, allow determining the risk of electrical myocardial instability, which is a pathophysiological mechanism underlying sudden arrhythmic death.
Conclusions. Markers of fibrosis such as aldosterone, galectin-3 and transforming growth factor-β1, which are measured in heart failure, hypertension, metabolic syndrome, myocardial infarction, atrial fibrillation, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, have been found to predict myocardial electrical instability. Prediction of myocardial electrical instability in patients with hypertension and coronary heart disease based on studies of the association between frequent ventricular arrhythmias and plasma biomarkers of fibrosis (aldosterone, galectin-3, and transforming growth factor-β1) has not been discussed in the literature. |
| first_indexed | 2024-12-18T01:55:21Z |
| format | Article |
| id | doaj.art-27a96994ba9d45c5856df778a03d3d77 |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-18T01:55:21Z |
| publishDate | 2021-04-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-27a96994ba9d45c5856df778a03d3d772022-12-21T21:24:55ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102021-04-0123229330310.14739/2310-1210.2021.2.205757The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review)V. P. Ivanov0Yu. Yu. Shushkovska1I. V. Danylchuk2V. Р. Shcherbak3T. Yu. Tsybrii4National Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineCNE “Vinnytsia Regional Clinical Medical-Diagnostic Center of Cardiovascular Pathology”, UkraineCNE “Vinnytsia Regional Clinical Medical-Diagnostic Center of Cardiovascular Pathology”, UkraineCNE “Vinnytsia Regional Clinical Medical-Diagnostic Center of Cardiovascular Pathology”, UkraineThe aim. To analyze scientific researches on studying the biomarkers of fibrosis based on a review of the most recent publications for the possibility to predict electrical myocardial instability development. In total, 101 sources of literature related to the role of fibrosis biomarkers in the past 5 years were analyzed. The review of the literature has shown that myocardial fibrosis іs considered to be an arrhythmogenic substrate for ventricular arrhythmias, as it provides structural and functional disorders of the cardiac electrical activity. Markers of fibrosis, which are measured in cardiac pathology, allow determining the risk of electrical myocardial instability, which is a pathophysiological mechanism underlying sudden arrhythmic death. Conclusions. Markers of fibrosis such as aldosterone, galectin-3 and transforming growth factor-β1, which are measured in heart failure, hypertension, metabolic syndrome, myocardial infarction, atrial fibrillation, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, have been found to predict myocardial electrical instability. Prediction of myocardial electrical instability in patients with hypertension and coronary heart disease based on studies of the association between frequent ventricular arrhythmias and plasma biomarkers of fibrosis (aldosterone, galectin-3, and transforming growth factor-β1) has not been discussed in the literature.http://zmj.zsmu.edu.ua/article/view/205757/228130aldosteronegalectin 3tgf-β1ventricular extrasystole |
| spellingShingle | V. P. Ivanov Yu. Yu. Shushkovska I. V. Danylchuk V. Р. Shcherbak T. Yu. Tsybrii The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review) Zaporožskij Medicinskij Žurnal aldosterone galectin 3 tgf-β1 ventricular extrasystole |
| title | The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review) |
| title_full | The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review) |
| title_fullStr | The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review) |
| title_full_unstemmed | The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review) |
| title_short | The role of fibrosis biomarkers in predicting the development of myocardial electrical instability (a literature review) |
| title_sort | role of fibrosis biomarkers in predicting the development of myocardial electrical instability a literature review |
| topic | aldosterone galectin 3 tgf-β1 ventricular extrasystole |
| url | http://zmj.zsmu.edu.ua/article/view/205757/228130 |
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