Dermatological concerns for women and girls with turner syndrome
IntroductionTurner syndrome (TS) is associated with distinct manifestations in women and girls including short stature, cardiac abnormalities, premature ovarian failure as well as dermatological features, including lymphedema, keloids, onychodystrophy, and acne. Although many dermatological concerns...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1235187/full |
| _version_ | 1827819402014228480 |
|---|---|
| author | David Rodriguez-Buritica David Rodriguez-Buritica Meaghan Mones Siddharth K. Prakash Siddharth K. Prakash Michelle Rivera Michelle Rivera Melissa Aldrich Melissa Aldrich Megan Rogge Kate Richardson Kate Richardson |
| author_facet | David Rodriguez-Buritica David Rodriguez-Buritica Meaghan Mones Siddharth K. Prakash Siddharth K. Prakash Michelle Rivera Michelle Rivera Melissa Aldrich Melissa Aldrich Megan Rogge Kate Richardson Kate Richardson |
| author_sort | David Rodriguez-Buritica |
| collection | DOAJ |
| description | IntroductionTurner syndrome (TS) is associated with distinct manifestations in women and girls including short stature, cardiac abnormalities, premature ovarian failure as well as dermatological features, including lymphedema, keloids, onychodystrophy, and acne. Although many dermatological concerns present during the first few decades of life, the overwhelming majority of respondents are not provided with dermatology referrals at diagnosis.MethodsThis cross-sectional study utilized an author designed survey to assess self-reported dermatological manifestations, dermatology referral experience, common therapies for select dermatological conditions, as well as a validated 10-question Dermatology Life Quality Index (DLQI) to assess quality-of-life impact in women and girls with Turner syndrome.ResultsIn our cohort, 64% (n = 149) had been referred to a dermatologist at some point in their life time. The majority of individuals self-identified their dermatological concern (79.6%) and were referred after a dermatological concern had already occurred (90.2%). The most common dermatological findings reported were xerosis cutis (78.7%), lymphedema (73%), and more than 20 acquired melanocytic nevi (70%). The overall mean DLQI score was 3.52, indicative of a small effect on the patient’s life. Onychodystrophy, history of skin biopsy, and lymphedema were statistically significant to have a higher impact on quality of life.DiscussionOur data reveal that skin conditions are highly prevalent in the TS population during the early decades of life and affirm utilizing these conditions in the TS diagnostic process, as well as emphasize the need for specialized dermatology referrals to address the detrimental impacts related to skin concerns on quality of life. |
| first_indexed | 2024-03-12T01:14:26Z |
| format | Article |
| id | doaj.art-27aa4bdb03e34b87a7b8c5325bea671c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T01:14:26Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-27aa4bdb03e34b87a7b8c5325bea671c2023-09-13T17:54:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-09-011010.3389/fmed.2023.12351871235187Dermatological concerns for women and girls with turner syndromeDavid Rodriguez-Buritica0David Rodriguez-Buritica1Meaghan Mones2Siddharth K. Prakash3Siddharth K. Prakash4Michelle Rivera5Michelle Rivera6Melissa Aldrich7Melissa Aldrich8Megan Rogge9Kate Richardson10Kate Richardson11Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children’s Memorial Hermann Hospital, Houston, TX, United StatesCancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United StatesCancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United StatesCancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United StatesDepartment of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston), Houston, TX, United StatesCancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United StatesDepartment of Pediatrics, Division of Pediatric Endocrinology, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children’s Memorial Hermann Hospital, Houston, TX, United StatesCancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United StatesBrown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children’s Memorial Hermann Hospital, Houston, TX, United StatesDepartment of Dermatology, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children’s Memorial Hermann Hospital, Houston, TX, United StatesDepartment of Pediatrics, Division of Medical Genetics, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children’s Memorial Hermann Hospital, Houston, TX, United StatesCancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United StatesIntroductionTurner syndrome (TS) is associated with distinct manifestations in women and girls including short stature, cardiac abnormalities, premature ovarian failure as well as dermatological features, including lymphedema, keloids, onychodystrophy, and acne. Although many dermatological concerns present during the first few decades of life, the overwhelming majority of respondents are not provided with dermatology referrals at diagnosis.MethodsThis cross-sectional study utilized an author designed survey to assess self-reported dermatological manifestations, dermatology referral experience, common therapies for select dermatological conditions, as well as a validated 10-question Dermatology Life Quality Index (DLQI) to assess quality-of-life impact in women and girls with Turner syndrome.ResultsIn our cohort, 64% (n = 149) had been referred to a dermatologist at some point in their life time. The majority of individuals self-identified their dermatological concern (79.6%) and were referred after a dermatological concern had already occurred (90.2%). The most common dermatological findings reported were xerosis cutis (78.7%), lymphedema (73%), and more than 20 acquired melanocytic nevi (70%). The overall mean DLQI score was 3.52, indicative of a small effect on the patient’s life. Onychodystrophy, history of skin biopsy, and lymphedema were statistically significant to have a higher impact on quality of life.DiscussionOur data reveal that skin conditions are highly prevalent in the TS population during the early decades of life and affirm utilizing these conditions in the TS diagnostic process, as well as emphasize the need for specialized dermatology referrals to address the detrimental impacts related to skin concerns on quality of life.https://www.frontiersin.org/articles/10.3389/fmed.2023.1235187/fullturner syndromemedical dermatologyquality of lifedermatological manifestationsxerosis cutiskeloids |
| spellingShingle | David Rodriguez-Buritica David Rodriguez-Buritica Meaghan Mones Siddharth K. Prakash Siddharth K. Prakash Michelle Rivera Michelle Rivera Melissa Aldrich Melissa Aldrich Megan Rogge Kate Richardson Kate Richardson Dermatological concerns for women and girls with turner syndrome Frontiers in Medicine turner syndrome medical dermatology quality of life dermatological manifestations xerosis cutis keloids |
| title | Dermatological concerns for women and girls with turner syndrome |
| title_full | Dermatological concerns for women and girls with turner syndrome |
| title_fullStr | Dermatological concerns for women and girls with turner syndrome |
| title_full_unstemmed | Dermatological concerns for women and girls with turner syndrome |
| title_short | Dermatological concerns for women and girls with turner syndrome |
| title_sort | dermatological concerns for women and girls with turner syndrome |
| topic | turner syndrome medical dermatology quality of life dermatological manifestations xerosis cutis keloids |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1235187/full |
| work_keys_str_mv | AT davidrodriguezburitica dermatologicalconcernsforwomenandgirlswithturnersyndrome AT davidrodriguezburitica dermatologicalconcernsforwomenandgirlswithturnersyndrome AT meaghanmones dermatologicalconcernsforwomenandgirlswithturnersyndrome AT siddharthkprakash dermatologicalconcernsforwomenandgirlswithturnersyndrome AT siddharthkprakash dermatologicalconcernsforwomenandgirlswithturnersyndrome AT michellerivera dermatologicalconcernsforwomenandgirlswithturnersyndrome AT michellerivera dermatologicalconcernsforwomenandgirlswithturnersyndrome AT melissaaldrich dermatologicalconcernsforwomenandgirlswithturnersyndrome AT melissaaldrich dermatologicalconcernsforwomenandgirlswithturnersyndrome AT meganrogge dermatologicalconcernsforwomenandgirlswithturnersyndrome AT katerichardson dermatologicalconcernsforwomenandgirlswithturnersyndrome AT katerichardson dermatologicalconcernsforwomenandgirlswithturnersyndrome |