Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
Abstract The recent incidence and management patterns of alcohol-related liver disease (ARLD) are not well defined in Korea. We sought to evaluate the epidemiology of ARLD with regard to disease severity and alcohol cessation management after diagnosis. We performed an observational cohort study of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-86197-z |
| _version_ | 1818840961653932032 |
|---|---|
| author | Ha Il Kim Seo Young Park Hyun Phil Shin |
| author_facet | Ha Il Kim Seo Young Park Hyun Phil Shin |
| author_sort | Ha Il Kim |
| collection | DOAJ |
| description | Abstract The recent incidence and management patterns of alcohol-related liver disease (ARLD) are not well defined in Korea. We sought to evaluate the epidemiology of ARLD with regard to disease severity and alcohol cessation management after diagnosis. We performed an observational cohort study of standardized Common Data Model data from the Health Insurance Review and Assessment-National Patient Samples database between 2012 and 2016. The incidence and demographic properties of ARLD were extracted and divided into non-cirrhotic alcoholic liver disease (ALD) and alcoholic liver cirrhosis (ALC). ALC was compared with non-alcoholic cirrhosis by severity at diagnosis. The management patterns were captured by the initiation of pharmaco- and behavioral therapy for alcohol cessation. We analyzed data from 72,556 ALD to 7295 ALC patients. The ALD incidence was stable from 990 to 1025 per 100,000 people. In ALD, the proportion of patients who were ≥ 65 years old, the proportion of female patients, and the comorbidity index increased significantly during the study period (all P values < 0.001). ALC accounted for > 20% of all cirrhosis, with decompensation occurring twice as often as in non-alcoholic cirrhosis. The initiation of alcoholism management was stationary in ARLD, remaining at < 10% for both pharmacotherapy and behavioral therapy, regardless of severity or the site of diagnosis. The incidence of ARLD did not decrease during the study period. Moreover, an increasing trend in the proportion of people vulnerable to drinking was observed. Unfortunately, management for the cessation of alcohol use remains very low. The best way to manage ARLD should be evaluated in further study. |
| first_indexed | 2024-12-19T04:18:30Z |
| format | Article |
| id | doaj.art-27ad70ac9e404352a3936ec877c918c9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:18:30Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-27ad70ac9e404352a3936ec877c918c92022-12-21T20:36:13ZengNature PortfolioScientific Reports2045-23222021-03-0111111110.1038/s41598-021-86197-zIncidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort studyHa Il Kim0Seo Young Park1Hyun Phil Shin2Division of Gastroenterology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of MedicineDepartment of Clinical Epidemiology and Biostatistics, Asan Medical CenterDivision of Gastroenterology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of MedicineAbstract The recent incidence and management patterns of alcohol-related liver disease (ARLD) are not well defined in Korea. We sought to evaluate the epidemiology of ARLD with regard to disease severity and alcohol cessation management after diagnosis. We performed an observational cohort study of standardized Common Data Model data from the Health Insurance Review and Assessment-National Patient Samples database between 2012 and 2016. The incidence and demographic properties of ARLD were extracted and divided into non-cirrhotic alcoholic liver disease (ALD) and alcoholic liver cirrhosis (ALC). ALC was compared with non-alcoholic cirrhosis by severity at diagnosis. The management patterns were captured by the initiation of pharmaco- and behavioral therapy for alcohol cessation. We analyzed data from 72,556 ALD to 7295 ALC patients. The ALD incidence was stable from 990 to 1025 per 100,000 people. In ALD, the proportion of patients who were ≥ 65 years old, the proportion of female patients, and the comorbidity index increased significantly during the study period (all P values < 0.001). ALC accounted for > 20% of all cirrhosis, with decompensation occurring twice as often as in non-alcoholic cirrhosis. The initiation of alcoholism management was stationary in ARLD, remaining at < 10% for both pharmacotherapy and behavioral therapy, regardless of severity or the site of diagnosis. The incidence of ARLD did not decrease during the study period. Moreover, an increasing trend in the proportion of people vulnerable to drinking was observed. Unfortunately, management for the cessation of alcohol use remains very low. The best way to manage ARLD should be evaluated in further study.https://doi.org/10.1038/s41598-021-86197-z |
| spellingShingle | Ha Il Kim Seo Young Park Hyun Phil Shin Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study Scientific Reports |
| title | Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study |
| title_full | Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study |
| title_fullStr | Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study |
| title_full_unstemmed | Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study |
| title_short | Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study |
| title_sort | incidence and management patterns of alcohol related liver disease in korea a nationwide standard cohort study |
| url | https://doi.org/10.1038/s41598-021-86197-z |
| work_keys_str_mv | AT hailkim incidenceandmanagementpatternsofalcoholrelatedliverdiseaseinkoreaanationwidestandardcohortstudy AT seoyoungpark incidenceandmanagementpatternsofalcoholrelatedliverdiseaseinkoreaanationwidestandardcohortstudy AT hyunphilshin incidenceandmanagementpatternsofalcoholrelatedliverdiseaseinkoreaanationwidestandardcohortstudy |