Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics
Background: The pattern of Gankyrin expression is dynamic in response to various stimuli; it is known to be upregulated in several types of cancer. Therefore, Gankyrin expression may serve as a novel prognostic marker of clinical importance and also be considered as a potential therapeutic target fo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Advances in Cancer Biology - Metastasis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266739402100023X |
| _version_ | 1818252896993542144 |
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| author | Dharmendra Kashyap Nidhi Varshney Hamendra Singh Parmar Hem Chandra Jha |
| author_facet | Dharmendra Kashyap Nidhi Varshney Hamendra Singh Parmar Hem Chandra Jha |
| author_sort | Dharmendra Kashyap |
| collection | DOAJ |
| description | Background: The pattern of Gankyrin expression is dynamic in response to various stimuli; it is known to be upregulated in several types of cancer. Therefore, Gankyrin expression may serve as a novel prognostic marker of clinical importance and also be considered as a potential therapeutic target for the development of drug candidates. Summary: Gankyrin or PSMD10 is an established oncoprotein and their elevated expressions are reported in several types of cancer. Gankyrin is involved in various biological processes including the transformation of cells followed by carcinogenesis and metastasis. Abnormal expression of Gankyrin has been reported in a variety of cancers including liver, pancreatic, esophageal, cervical, lung, breast, and glioma. Notably, elevated expression of Gankyrin modulates the key signaling pathways such as JNK, PI3K/AKT, and mTOR, avidly involved in the regulation of cell cycle, apoptosis, and cell fate decisions, thus resulting in the process of tumorigenesis and metastasis. Contrastingly, downregulated expression of Gankyrin exerts anticancer effects. Evidently, a number of emerging reports revealed Gankyrin as a potential marker for the early detection of various cancers. Therefore, it is consistent with the notion that Gankyrin is a driver gene that serves not only to initiate the process of carcinogenesis, but also to progress into metastatic phenotype. All of the aforementioned properties of Gankyrin are providing an emerging need to explore it as an early diagnosis marker, prognostic marker, and a potential therapeutic target to develop putative drug candidates to treat various cancer types. |
| first_indexed | 2024-12-12T16:31:28Z |
| format | Article |
| id | doaj.art-27adadd42e60462e830f444f4a97f5b6 |
| institution | Directory Open Access Journal |
| issn | 2667-3940 |
| language | English |
| last_indexed | 2024-12-12T16:31:28Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj.art-27adadd42e60462e830f444f4a97f5b62022-12-22T00:18:46ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402022-07-014100023Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeuticsDharmendra Kashyap0Nidhi Varshney1Hamendra Singh Parmar2Hem Chandra Jha3Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, IndiaDepartment of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, IndiaSchool of Biotechnology, Devi Ahilya Vishwa vidyalaya Indore, MP, Indore, IndiaDepartment of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, India; Corresponding author. Infection Bio-engineering group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Madhya Pradesh, PIN-453552, India.Background: The pattern of Gankyrin expression is dynamic in response to various stimuli; it is known to be upregulated in several types of cancer. Therefore, Gankyrin expression may serve as a novel prognostic marker of clinical importance and also be considered as a potential therapeutic target for the development of drug candidates. Summary: Gankyrin or PSMD10 is an established oncoprotein and their elevated expressions are reported in several types of cancer. Gankyrin is involved in various biological processes including the transformation of cells followed by carcinogenesis and metastasis. Abnormal expression of Gankyrin has been reported in a variety of cancers including liver, pancreatic, esophageal, cervical, lung, breast, and glioma. Notably, elevated expression of Gankyrin modulates the key signaling pathways such as JNK, PI3K/AKT, and mTOR, avidly involved in the regulation of cell cycle, apoptosis, and cell fate decisions, thus resulting in the process of tumorigenesis and metastasis. Contrastingly, downregulated expression of Gankyrin exerts anticancer effects. Evidently, a number of emerging reports revealed Gankyrin as a potential marker for the early detection of various cancers. Therefore, it is consistent with the notion that Gankyrin is a driver gene that serves not only to initiate the process of carcinogenesis, but also to progress into metastatic phenotype. All of the aforementioned properties of Gankyrin are providing an emerging need to explore it as an early diagnosis marker, prognostic marker, and a potential therapeutic target to develop putative drug candidates to treat various cancer types.http://www.sciencedirect.com/science/article/pii/S266739402100023XGankyrinVirusesCancerp53 tumor suppressor proteinGankyrin inhibitor |
| spellingShingle | Dharmendra Kashyap Nidhi Varshney Hamendra Singh Parmar Hem Chandra Jha Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics Advances in Cancer Biology - Metastasis Gankyrin Viruses Cancer p53 tumor suppressor protein Gankyrin inhibitor |
| title | Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics |
| title_full | Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics |
| title_fullStr | Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics |
| title_full_unstemmed | Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics |
| title_short | Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics |
| title_sort | gankyrin at the crossroads of cancer diagnosis disease prognosis and development of efficient cancer therapeutics |
| topic | Gankyrin Viruses Cancer p53 tumor suppressor protein Gankyrin inhibitor |
| url | http://www.sciencedirect.com/science/article/pii/S266739402100023X |
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