Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children
Background: RSV often leads to hospitalization, and accurate knowledge of risk factors is crucial. Methods: We retrospectively analyzed laboratory-confirmed RSV hospitalizations regarding pregnancy factors, birth status, cigarette smoke exposure, nutrition, social conditions, clinical presentation,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/8/1713 |
| _version_ | 1797582989947830272 |
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| author | Małgorzata Kobiałka Teresa Jackowska August Wrotek |
| author_facet | Małgorzata Kobiałka Teresa Jackowska August Wrotek |
| author_sort | Małgorzata Kobiałka |
| collection | DOAJ |
| description | Background: RSV often leads to hospitalization, and accurate knowledge of risk factors is crucial. Methods: We retrospectively analyzed laboratory-confirmed RSV hospitalizations regarding pregnancy factors, birth status, cigarette smoke exposure, nutrition, social conditions, clinical presentation, and severe disease defined as a need for passive oxygen therapy (pO2Tx), the presence of pneumonia, respiratory failure, intensive care unit (ICU) transfer, and prolonged hospitalization. Results: A univariate analysis included 594 children (median age 4 months) and revealed a pO2Tx relationship with age ≤ 3 months (OR = 1.56), prematurity (OR = 1.71), being born during RSV season (OR = 1.72), smoke exposure during pregnancy (both parents (OR = 2.41, father (OR = 1.8)), dyspnea (OR = 5.09), and presence of apnea (OR = 5.81). Pneumonia was associated with maternal smoke exposure (OR = 5.01), fever (OR = 3.92), dyspnea (OR = 1.62), history of aspiration (OR = 4.63), and inversely with age ≤ 3 months (OR = 0.45). Respiratory failure was associated with prematurity (OR = 3.13) and apnea (OR = 18.78), while the lower odds were associated with older age (OR = 0.57 per month) and presence of fever (OR = 0.11). ICU transfer was associated with apnea (OR = 17.18), but an inverse association was observed with age (OR = 0.54) and fever (OR = 0.11). A prolonged hospital stay was associated with prematurity (OR = 1.76), low birth weight (OR = 2.89), aspiration (OR = 4.93), and presence of fever (OR = 1.51). Conclusions: Age (up to 3 months), prematurity, and presence of apnea are risk factors for a severe RSV course. |
| first_indexed | 2024-03-10T23:30:27Z |
| format | Article |
| id | doaj.art-27adc2933ac44b80948aa92d05fd923b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T23:30:27Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-27adc2933ac44b80948aa92d05fd923b2023-11-19T03:20:43ZengMDPI AGViruses1999-49152023-08-01158171310.3390/v15081713Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized ChildrenMałgorzata Kobiałka0Teresa Jackowska1August Wrotek2Department of Pediatrics, Bielanski Hospital, 01-809 Warsaw, PolandDepartment of Pediatrics, Bielanski Hospital, 01-809 Warsaw, PolandDepartment of Pediatrics, Bielanski Hospital, 01-809 Warsaw, PolandBackground: RSV often leads to hospitalization, and accurate knowledge of risk factors is crucial. Methods: We retrospectively analyzed laboratory-confirmed RSV hospitalizations regarding pregnancy factors, birth status, cigarette smoke exposure, nutrition, social conditions, clinical presentation, and severe disease defined as a need for passive oxygen therapy (pO2Tx), the presence of pneumonia, respiratory failure, intensive care unit (ICU) transfer, and prolonged hospitalization. Results: A univariate analysis included 594 children (median age 4 months) and revealed a pO2Tx relationship with age ≤ 3 months (OR = 1.56), prematurity (OR = 1.71), being born during RSV season (OR = 1.72), smoke exposure during pregnancy (both parents (OR = 2.41, father (OR = 1.8)), dyspnea (OR = 5.09), and presence of apnea (OR = 5.81). Pneumonia was associated with maternal smoke exposure (OR = 5.01), fever (OR = 3.92), dyspnea (OR = 1.62), history of aspiration (OR = 4.63), and inversely with age ≤ 3 months (OR = 0.45). Respiratory failure was associated with prematurity (OR = 3.13) and apnea (OR = 18.78), while the lower odds were associated with older age (OR = 0.57 per month) and presence of fever (OR = 0.11). ICU transfer was associated with apnea (OR = 17.18), but an inverse association was observed with age (OR = 0.54) and fever (OR = 0.11). A prolonged hospital stay was associated with prematurity (OR = 1.76), low birth weight (OR = 2.89), aspiration (OR = 4.93), and presence of fever (OR = 1.51). Conclusions: Age (up to 3 months), prematurity, and presence of apnea are risk factors for a severe RSV course.https://www.mdpi.com/1999-4915/15/8/1713respiratory syncytial virusbronchiolitisclinical courserisk factorspediatricschildren |
| spellingShingle | Małgorzata Kobiałka Teresa Jackowska August Wrotek Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children Viruses respiratory syncytial virus bronchiolitis clinical course risk factors pediatrics children |
| title | Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children |
| title_full | Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children |
| title_fullStr | Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children |
| title_full_unstemmed | Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children |
| title_short | Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children |
| title_sort | risk factors for severe respiratory syncytial virus infection in hospitalized children |
| topic | respiratory syncytial virus bronchiolitis clinical course risk factors pediatrics children |
| url | https://www.mdpi.com/1999-4915/15/8/1713 |
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