Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy production and free radical maintenance. However, mitochondrial me...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1284410/full |
| _version_ | 1827752043932024832 |
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| author | Ines Martic Ines Martic Federica Papaccio Barbara Bellei Maria Cavinato Maria Cavinato |
| author_facet | Ines Martic Ines Martic Federica Papaccio Barbara Bellei Maria Cavinato Maria Cavinato |
| author_sort | Ines Martic |
| collection | DOAJ |
| description | Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy production and free radical maintenance. However, mitochondrial metabolism as well as processes of mitochondrial dynamics, biogenesis, and degradation varies considerably among the different types of cells that populate the skin. Disturbed mitochondrial function is known to promote aging and inflammation of the skin, leading to impairment of physiological skin function and the onset of skin pathologies. In this review, we discuss the essential role of mitochondria in different skin cell types and how impairment of mitochondrial morphology, physiology, and metabolism in each of these cellular compartments of the skin contributes to the process of skin aging. |
| first_indexed | 2024-03-11T07:05:17Z |
| format | Article |
| id | doaj.art-27afa50ce4974720bac219df9de3fc6a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-11T07:05:17Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-27afa50ce4974720bac219df9de3fc6a2023-11-17T08:56:02ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-11-011410.3389/fphys.2023.12844101284410Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and agingInes Martic0Ines Martic1Federica Papaccio2Barbara Bellei3Maria Cavinato4Maria Cavinato5Institute for Biochemical Aging Research, University of Innsbruck, Innsbruck, AustriaCenter for Molecular Biosciences Innsbruck (CMBI), Innsbruck, AustriaLaboratory of Cutaneous Physiopathology and Integrated Center for Metabolomics Research, San Gallicano Dermatological Institute, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, ItalyLaboratory of Cutaneous Physiopathology and Integrated Center for Metabolomics Research, San Gallicano Dermatological Institute, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, ItalyInstitute for Biochemical Aging Research, University of Innsbruck, Innsbruck, AustriaCenter for Molecular Biosciences Innsbruck (CMBI), Innsbruck, AustriaAging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy production and free radical maintenance. However, mitochondrial metabolism as well as processes of mitochondrial dynamics, biogenesis, and degradation varies considerably among the different types of cells that populate the skin. Disturbed mitochondrial function is known to promote aging and inflammation of the skin, leading to impairment of physiological skin function and the onset of skin pathologies. In this review, we discuss the essential role of mitochondria in different skin cell types and how impairment of mitochondrial morphology, physiology, and metabolism in each of these cellular compartments of the skin contributes to the process of skin aging.https://www.frontiersin.org/articles/10.3389/fphys.2023.1284410/fullskinagingmitochondriaskin homeostasisskin cells |
| spellingShingle | Ines Martic Ines Martic Federica Papaccio Barbara Bellei Maria Cavinato Maria Cavinato Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging Frontiers in Physiology skin aging mitochondria skin homeostasis skin cells |
| title | Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging |
| title_full | Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging |
| title_fullStr | Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging |
| title_full_unstemmed | Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging |
| title_short | Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging |
| title_sort | mitochondrial dynamics and metabolism across skin cells implications for skin homeostasis and aging |
| topic | skin aging mitochondria skin homeostasis skin cells |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1284410/full |
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