Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial
Background: The optimal treatment for cutaneous leishmaniasis (CL) has not been established. Topical paromomycin is one of the many drugs that have been suggested for the treatment of CL caused by leishmania major. Recently, photodynamic therapy (PDT) has been reported to be effective in the treatme...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2012-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1725 |
| _version_ | 1797715897961414656 |
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| author | ALi Asilian Majid Davami |
| author_facet | ALi Asilian Majid Davami |
| author_sort | ALi Asilian |
| collection | DOAJ |
| description | Background: The optimal treatment for cutaneous leishmaniasis (CL) has not been established. Topical paromomycin is one of the many drugs that have been suggested for the treatment of CL caused by leishmania major. Recently, photodynamic therapy (PDT) has been reported to be effective in the treatment of CL. The aim of the present study was to compare the parasitological and clinical efficacy of PDT versus topical paromomycin in patients with old world CL caused by leishmania major in Iran.
Methods: In this trial, 60 patients with the clinical and parasitological diagnosis of CL were recruited and were randomly divided in to three treatment groups of 20 subjects each. Group 1 was treated with weekly topical PDT, and groups 2 and 3 received twice-daily topical paromomycin and placebo, respectively. The duration of treatment was 4 weeks for all groups. These groups were followed for 2 months after termination of treatment.
Findings: In total, 57 patients with 95 lesions completed the study. At the end of thestudy, complete improvement was seen in 29 out of 31 (93.5%), 14 out of 34 (41.2%) and 4 out of 30 lesions (13.3%) in groups 1, 2 and 3, respectively (P < 0.001). At the same timepoint, 100%, 64.7%, and 20% of the lesions had parasitological cure in groups 1, 2 and 3, respectively (P < 0.001).
Conclusion: Topical PDT can be used safely as a rapid and highly effective alternative treatment choice for old world CL in selected patients. |
| first_indexed | 2024-03-12T08:13:37Z |
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| id | doaj.art-27b0ffc1a84940779f53ff3d1d8808d6 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:13:37Z |
| publishDate | 2012-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-27b0ffc1a84940779f53ff3d1d8808d62023-09-02T19:01:17ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-03-0129173895Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical TrialALi Asilian0Majid Davami1Professor, Skin Disease and Cutaneous Leishmaniasis Research Center And Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranResident, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran And Department of Dermatology, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: The optimal treatment for cutaneous leishmaniasis (CL) has not been established. Topical paromomycin is one of the many drugs that have been suggested for the treatment of CL caused by leishmania major. Recently, photodynamic therapy (PDT) has been reported to be effective in the treatment of CL. The aim of the present study was to compare the parasitological and clinical efficacy of PDT versus topical paromomycin in patients with old world CL caused by leishmania major in Iran. Methods: In this trial, 60 patients with the clinical and parasitological diagnosis of CL were recruited and were randomly divided in to three treatment groups of 20 subjects each. Group 1 was treated with weekly topical PDT, and groups 2 and 3 received twice-daily topical paromomycin and placebo, respectively. The duration of treatment was 4 weeks for all groups. These groups were followed for 2 months after termination of treatment. Findings: In total, 57 patients with 95 lesions completed the study. At the end of thestudy, complete improvement was seen in 29 out of 31 (93.5%), 14 out of 34 (41.2%) and 4 out of 30 lesions (13.3%) in groups 1, 2 and 3, respectively (P < 0.001). At the same timepoint, 100%, 64.7%, and 20% of the lesions had parasitological cure in groups 1, 2 and 3, respectively (P < 0.001). Conclusion: Topical PDT can be used safely as a rapid and highly effective alternative treatment choice for old world CL in selected patients.http://jims.mui.ac.ir/index.php/jims/article/view/1725Photodynamic therapyParomomycinCutaneous leishmaniasis |
| spellingShingle | ALi Asilian Majid Davami Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial مجله دانشکده پزشکی اصفهان Photodynamic therapy Paromomycin Cutaneous leishmaniasis |
| title | Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial |
| title_full | Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial |
| title_fullStr | Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial |
| title_full_unstemmed | Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial |
| title_short | Comparison between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-controlled, Randomized Clinical Trial |
| title_sort | comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of old world cutaneous leishmaniasis a placebo controlled randomized clinical trial |
| topic | Photodynamic therapy Paromomycin Cutaneous leishmaniasis |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1725 |
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