Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma

Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma

Cutaneous T-cell lymphoma (CTCL) is a severe lymphoid malignancy with a worse prognosis lacking curative treatment regimens. Several gene mutations and deregulated pathways, including NFkB signaling, have been implicated in its pathogenesis. Accordingly, CTCL cell line HUT-78 reportedly contains mut...

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Bibliographic Details
Main Authors: Stefan Nagel, Claudia Pommerenke, Hilmar Quentmeier, Corinna Meyer, Maren Kaufmann, Roderick A. F. MacLeod
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
T-ALL
TPL1XR1::TP63
MOTN-1
Online Access:https://www.mdpi.com/2227-9059/10/8/2038

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