The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease
AbstractIntroduction Insulin resistance (IR) plays an important role in the occurrence and development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). The triglyceride-glucose (TyG) index is a simple and effective tool to evaluate IR. This study aimed to evaluate the a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2320261 |
| _version_ | 1797230978690711552 |
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| author | Dan Liu Xiaoyang Guan Ruoxin Chen Ci Song Shanhu Qiu Shengchun Xu Jingyuan Cao Hong Liu |
| author_facet | Dan Liu Xiaoyang Guan Ruoxin Chen Ci Song Shanhu Qiu Shengchun Xu Jingyuan Cao Hong Liu |
| author_sort | Dan Liu |
| collection | DOAJ |
| description | AbstractIntroduction Insulin resistance (IR) plays an important role in the occurrence and development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). The triglyceride-glucose (TyG) index is a simple and effective tool to evaluate IR. This study aimed to evaluate the association of the TyG index with coronary artery disease (CAD) and the severity of coronary artery stenosis (CAS) in nondialysis patients with stages 3–5 CKD.Methods Nondialysis patients with stages 3–5 CKD who underwent the first coronary angiography at Zhongda Hospital affiliated with Southeast University from August 2015 to January 2017 were retrospectively analyzed. CAS was measured by coronary angiography, and the CAS score was calculated as the Gensini score. Logistic regression analysis was used to determine the related factors of CAD and severe CAS.Results A total of 943 patients were enrolled in this cross-sectional study and 720 (76.4%) of these patients were diagnosed with CAD. The TyG index in the CAD group (7.29 ± 0.63) was significantly higher than that in the non-CAD group (7.11 ± 0.61) (p < 0.001). Multivariate logistic regression analysis showed that a higher TyG index was an independent risk factor for CAD in CKD patients after adjusting for related confounding factors (OR = 2.865, 95% CI 1.681–4.885, p < 0.001). Patients in the CAD group were divided into three groups according to the Gensini integral quantile level. Multivariate logistic regression analysis showed that the TyG index was an independent related factor for severe CAS after adjusting for relevant confounding factors (p < 0.001).Conclusions The TyG index is associated with CAD and the severity of CAS in patients with nondialysis stages 3–5 CKD. A higher TyG index is an independent factor for CAD and severe CAS. |
| first_indexed | 2024-03-07T21:20:41Z |
| format | Article |
| id | doaj.art-27b1722a50bf4975a68fa83f5b1f7f9c |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T15:37:05Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-27b1722a50bf4975a68fa83f5b1f7f9c2024-04-02T01:29:26ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2320261The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney diseaseDan Liu0Xiaoyang Guan1Ruoxin Chen2Ci Song3Shanhu Qiu4Shengchun Xu5Jingyuan Cao6Hong Liu7Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, P.R. ChinaInstitute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, P.R. ChinaInstitute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, P.R. ChinaResearch and Education Centre of General Practice, Zhong Da Hospital, Southeast University, Nanjing, P.R. ChinaResearch and Education Centre of General Practice, Zhong Da Hospital, Southeast University, Nanjing, P.R. ChinaInstitute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, P.R. ChinaDepartment of Nephrology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, P.R. ChinaInstitute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, P.R. ChinaAbstractIntroduction Insulin resistance (IR) plays an important role in the occurrence and development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). The triglyceride-glucose (TyG) index is a simple and effective tool to evaluate IR. This study aimed to evaluate the association of the TyG index with coronary artery disease (CAD) and the severity of coronary artery stenosis (CAS) in nondialysis patients with stages 3–5 CKD.Methods Nondialysis patients with stages 3–5 CKD who underwent the first coronary angiography at Zhongda Hospital affiliated with Southeast University from August 2015 to January 2017 were retrospectively analyzed. CAS was measured by coronary angiography, and the CAS score was calculated as the Gensini score. Logistic regression analysis was used to determine the related factors of CAD and severe CAS.Results A total of 943 patients were enrolled in this cross-sectional study and 720 (76.4%) of these patients were diagnosed with CAD. The TyG index in the CAD group (7.29 ± 0.63) was significantly higher than that in the non-CAD group (7.11 ± 0.61) (p < 0.001). Multivariate logistic regression analysis showed that a higher TyG index was an independent risk factor for CAD in CKD patients after adjusting for related confounding factors (OR = 2.865, 95% CI 1.681–4.885, p < 0.001). Patients in the CAD group were divided into three groups according to the Gensini integral quantile level. Multivariate logistic regression analysis showed that the TyG index was an independent related factor for severe CAS after adjusting for relevant confounding factors (p < 0.001).Conclusions The TyG index is associated with CAD and the severity of CAS in patients with nondialysis stages 3–5 CKD. A higher TyG index is an independent factor for CAD and severe CAS.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2320261TyG indexcoronary artery diseaseseverity of coronary artery stenosischronic kidney disease |
| spellingShingle | Dan Liu Xiaoyang Guan Ruoxin Chen Ci Song Shanhu Qiu Shengchun Xu Jingyuan Cao Hong Liu The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease Renal Failure TyG index coronary artery disease severity of coronary artery stenosis chronic kidney disease |
| title | The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease |
| title_full | The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease |
| title_fullStr | The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease |
| title_full_unstemmed | The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease |
| title_short | The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease |
| title_sort | clinical evaluation of the triglyceride glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease |
| topic | TyG index coronary artery disease severity of coronary artery stenosis chronic kidney disease |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2320261 |
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