Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction.
A naturally-occurring fragment of tyrosyl-tRNA synthetase (TyrRS) has been shown in higher eukaryotes to 'moonlight' as a pro-angiogenic cytokine in addition to its primary role in protein translation. Pro-angiogenic cytokines have previously been proposed to be promising therapeutic mecha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4190278?pdf=render |
| _version_ | 1818974383205515264 |
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| author | Margaret E McCormick Mauricio Rojas Tyler Moser-Katz Ellie Tzima John S Reader |
| author_facet | Margaret E McCormick Mauricio Rojas Tyler Moser-Katz Ellie Tzima John S Reader |
| author_sort | Margaret E McCormick |
| collection | DOAJ |
| description | A naturally-occurring fragment of tyrosyl-tRNA synthetase (TyrRS) has been shown in higher eukaryotes to 'moonlight' as a pro-angiogenic cytokine in addition to its primary role in protein translation. Pro-angiogenic cytokines have previously been proposed to be promising therapeutic mechanisms for the treatment of myocardial infarction. Here, we show that systemic delivery of the natural fragment of TyRS, mini-TyrRS, improves heart function in mice after myocardial infarction. This improvement is associated with reduced formation of scar tissue, increased angiogenesis of cardiac capillaries, recruitment of c-kitpos cells and proliferation of myocardial fibroblasts. This work demonstrates that mini-TyrRS has beneficial effects on cardiac repair and regeneration and offers support for the notion that elucidation of the ever expanding repertoire of noncanonical functions of aminoacyl tRNA synthetases offers unique opportunities for development of novel therapeutics. |
| first_indexed | 2024-12-20T15:39:11Z |
| format | Article |
| id | doaj.art-27b1f19dd8394b06ba0d283e4b6abda3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T15:39:11Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-27b1f19dd8394b06ba0d283e4b6abda32022-12-21T19:35:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e10932510.1371/journal.pone.0109325Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction.Margaret E McCormickMauricio RojasTyler Moser-KatzEllie TzimaJohn S ReaderA naturally-occurring fragment of tyrosyl-tRNA synthetase (TyrRS) has been shown in higher eukaryotes to 'moonlight' as a pro-angiogenic cytokine in addition to its primary role in protein translation. Pro-angiogenic cytokines have previously been proposed to be promising therapeutic mechanisms for the treatment of myocardial infarction. Here, we show that systemic delivery of the natural fragment of TyRS, mini-TyrRS, improves heart function in mice after myocardial infarction. This improvement is associated with reduced formation of scar tissue, increased angiogenesis of cardiac capillaries, recruitment of c-kitpos cells and proliferation of myocardial fibroblasts. This work demonstrates that mini-TyrRS has beneficial effects on cardiac repair and regeneration and offers support for the notion that elucidation of the ever expanding repertoire of noncanonical functions of aminoacyl tRNA synthetases offers unique opportunities for development of novel therapeutics.http://europepmc.org/articles/PMC4190278?pdf=render |
| spellingShingle | Margaret E McCormick Mauricio Rojas Tyler Moser-Katz Ellie Tzima John S Reader Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction. PLoS ONE |
| title | Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction. |
| title_full | Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction. |
| title_fullStr | Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction. |
| title_full_unstemmed | Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction. |
| title_short | Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction. |
| title_sort | natural aminoacyl trna synthetase fragment enhances cardiac function after myocardial infarction |
| url | http://europepmc.org/articles/PMC4190278?pdf=render |
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