Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease
Diabetes mellitus (DM), diabetic nephropathy (DN) and chronic kidney disease (CKD) are prevalent diseases in our region, South America. The levels of hemoglobin A1c (HbA1c) have been related to the development and progression of the DN. Two decades ago there was great variability in the results; the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Asociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires
2017-12-01
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| Series: | Revista de Nefrología, Diálisis y Trasplante |
| Subjects: | |
| Online Access: | http://www.revistarenal.org.ar/index.php/rndt/article/view/204 |
| _version_ | 1818651708749774848 |
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| author | Alicia G. Cercado Graciela B. Álvarez Conde Mariana E. Guadalupe Vargas Betty J. Pazmiño Gómez Dolores Veron Fanny E. Vera Lorenti Edgar I. Rodas Neira Enrique Fariño Maitén Fernández Veron Vicenta Cevallos Guillermo Villegas Elvira Arrizurieta Delma Veron |
| author_facet | Alicia G. Cercado Graciela B. Álvarez Conde Mariana E. Guadalupe Vargas Betty J. Pazmiño Gómez Dolores Veron Fanny E. Vera Lorenti Edgar I. Rodas Neira Enrique Fariño Maitén Fernández Veron Vicenta Cevallos Guillermo Villegas Elvira Arrizurieta Delma Veron |
| author_sort | Alicia G. Cercado |
| collection | DOAJ |
| description | Diabetes mellitus (DM), diabetic nephropathy (DN) and chronic kidney disease (CKD) are prevalent diseases in our region, South America. The levels of hemoglobin A1c (HbA1c) have been related to the development and progression of the DN. Two decades ago there was great variability in the results; the leading countries in scientific research then organized programs of HbA1c standardization, which improved the quality and reliability of the findings. The objectives of this study were to describe the problem of DM, DN and CKD in South America and to analyze HbA1c methodologically in this context. Thus, the impact of these diseases in our region was reviewed, contemplating basic aspects of HbA1c and some situations that produce interferences such as carbamylation of hemoglobin, the post-translational modification associated with uremia. We also focused on statistical techniques universally used for the evaluation of assays such as linearity, concordance and precision. Additionally, we included an analysis of the existing methods and the prices of each HbA1c determination in ten countries in South America.
To prevent, diagnose and treat DM, DN and CKD, it is essential to have state-of-theart tools available to all people. In our region, access to trials, equipment and laboratories within HbA1c standardization programs, internationally accepted, is a pending task. Millions of individuals from the present and future generations of South America will suffer from DM, DN and CKD, so we need to take the voice of science to these people through the daily "doing". |
| first_indexed | 2024-12-17T02:10:25Z |
| format | Article |
| id | doaj.art-27b52558ae2c4702a3a53e0831b8bcac |
| institution | Directory Open Access Journal |
| issn | 0326-3428 2346-8548 |
| language | Spanish |
| last_indexed | 2024-12-17T02:10:25Z |
| publishDate | 2017-12-01 |
| publisher | Asociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires |
| record_format | Article |
| series | Revista de Nefrología, Diálisis y Trasplante |
| spelling | doaj.art-27b52558ae2c4702a3a53e0831b8bcac2022-12-21T22:07:34ZspaAsociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos AiresRevista de Nefrología, Diálisis y Trasplante0326-34282346-85482017-12-01374225242201Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney DiseaseAlicia G. Cercado0Graciela B. Álvarez Conde1Mariana E. Guadalupe Vargas2Betty J. Pazmiño Gómez3Dolores Veron4Fanny E. Vera Lorenti5Edgar I. Rodas Neira6Enrique Fariño7Maitén Fernández Veron8Vicenta Cevallos9Guillermo Villegas10Elvira Arrizurieta11Delma Veron12Facultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroFacultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroFacultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroFacultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroFacultad de Ciencias Sociales, Escuela de Trabajo Social, Universidad Nacional de Córdoba, CórdobaFacultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroLaboratorio Clínico y Microbiológico Pazmiño, MilagroFacultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroFacultad de Arquitectura, Diseño y Urbanismo, Universidad de Buenos Aires, Buenos AiresLaboratorio Interlab, GuayaquilAlbert Einstein College of Medicine, Department of Urology, Yeshiva University, Nueva YorkServicio de Nefrología Experimental, Instituto Dr. Alfredo Lanari, Universidad de Buenos Aires, Buenos AiresFacultad de Ciencias de la Salud, Universidad Estatal de Milagro, MilagroDiabetes mellitus (DM), diabetic nephropathy (DN) and chronic kidney disease (CKD) are prevalent diseases in our region, South America. The levels of hemoglobin A1c (HbA1c) have been related to the development and progression of the DN. Two decades ago there was great variability in the results; the leading countries in scientific research then organized programs of HbA1c standardization, which improved the quality and reliability of the findings. The objectives of this study were to describe the problem of DM, DN and CKD in South America and to analyze HbA1c methodologically in this context. Thus, the impact of these diseases in our region was reviewed, contemplating basic aspects of HbA1c and some situations that produce interferences such as carbamylation of hemoglobin, the post-translational modification associated with uremia. We also focused on statistical techniques universally used for the evaluation of assays such as linearity, concordance and precision. Additionally, we included an analysis of the existing methods and the prices of each HbA1c determination in ten countries in South America. To prevent, diagnose and treat DM, DN and CKD, it is essential to have state-of-theart tools available to all people. In our region, access to trials, equipment and laboratories within HbA1c standardization programs, internationally accepted, is a pending task. Millions of individuals from the present and future generations of South America will suffer from DM, DN and CKD, so we need to take the voice of science to these people through the daily "doing".http://www.revistarenal.org.ar/index.php/rndt/article/view/204HbA1cdiabetes mellitusnefropatía diabéticaenfermedad renal crónicamétodosconcordanciaprecisióncostos |
| spellingShingle | Alicia G. Cercado Graciela B. Álvarez Conde Mariana E. Guadalupe Vargas Betty J. Pazmiño Gómez Dolores Veron Fanny E. Vera Lorenti Edgar I. Rodas Neira Enrique Fariño Maitén Fernández Veron Vicenta Cevallos Guillermo Villegas Elvira Arrizurieta Delma Veron Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease Revista de Nefrología, Diálisis y Trasplante HbA1c diabetes mellitus nefropatía diabética enfermedad renal crónica métodos concordancia precisión costos |
| title | Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease |
| title_full | Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease |
| title_fullStr | Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease |
| title_full_unstemmed | Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease |
| title_short | Hemoglobin A1c, Diabetes Mellitus, Diabetic Nephropathy and Chronic Kidney Disease |
| title_sort | hemoglobin a1c diabetes mellitus diabetic nephropathy and chronic kidney disease |
| topic | HbA1c diabetes mellitus nefropatía diabética enfermedad renal crónica métodos concordancia precisión costos |
| url | http://www.revistarenal.org.ar/index.php/rndt/article/view/204 |
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