Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14450 |
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| author | Ivan M. Veselov Daria V. Vinogradova Andrey V. Maltsev Pavel N. Shevtsov Elena A. Spirkova Sergey O. Bachurin Elena F. Shevtsova |
| author_facet | Ivan M. Veselov Daria V. Vinogradova Andrey V. Maltsev Pavel N. Shevtsov Elena A. Spirkova Sergey O. Bachurin Elena F. Shevtsova |
| author_sort | Ivan M. Veselov |
| collection | DOAJ |
| description | This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for both pathologies is aging. Common pathological mechanisms include both factors in the development of oxidative stress, neuroinflammation, insulin resistance, and amyloidosis, as well as impaired mitochondrial dysfunctions and increasing cell death. The currently available drugs for the treatment of type 2 diabetes and Alzheimer’s disease have limited therapeutic efficacy. It is important to note that drugs used to treat Alzheimer’s disease, in particular acetylcholinesterase inhibitors, show a positive therapeutic potential in the treatment of type 2 diabetes, while drugs used in the treatment of type 2 diabetes can also prevent a number of pathologies characteristic for Alzheimer’s disease. A promising direction in the search for a strategy for the treatment of type 2 diabetes and Alzheimer’s disease may be the creation of complex multi-target drugs that have neuroprotective potential and affect specific common targets for type 2 diabetes and Alzheimer’s disease. |
| first_indexed | 2024-03-10T21:43:25Z |
| format | Article |
| id | doaj.art-27b53a80b455498bb999354c3fafc63d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:25Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-27b53a80b455498bb999354c3fafc63d2023-11-19T14:26:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191445010.3390/ijms241914450Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes MellitusIvan M. Veselov0Daria V. Vinogradova1Andrey V. Maltsev2Pavel N. Shevtsov3Elena A. Spirkova4Sergey O. Bachurin5Elena F. Shevtsova6Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, RussiaThis review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for both pathologies is aging. Common pathological mechanisms include both factors in the development of oxidative stress, neuroinflammation, insulin resistance, and amyloidosis, as well as impaired mitochondrial dysfunctions and increasing cell death. The currently available drugs for the treatment of type 2 diabetes and Alzheimer’s disease have limited therapeutic efficacy. It is important to note that drugs used to treat Alzheimer’s disease, in particular acetylcholinesterase inhibitors, show a positive therapeutic potential in the treatment of type 2 diabetes, while drugs used in the treatment of type 2 diabetes can also prevent a number of pathologies characteristic for Alzheimer’s disease. A promising direction in the search for a strategy for the treatment of type 2 diabetes and Alzheimer’s disease may be the creation of complex multi-target drugs that have neuroprotective potential and affect specific common targets for type 2 diabetes and Alzheimer’s disease.https://www.mdpi.com/1422-0067/24/19/14450neurodegenerative diseasediabetesmitochondriaoxidative stressneuroinflammationamyloidosis |
| spellingShingle | Ivan M. Veselov Daria V. Vinogradova Andrey V. Maltsev Pavel N. Shevtsov Elena A. Spirkova Sergey O. Bachurin Elena F. Shevtsova Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus International Journal of Molecular Sciences neurodegenerative disease diabetes mitochondria oxidative stress neuroinflammation amyloidosis |
| title | Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus |
| title_full | Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus |
| title_fullStr | Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus |
| title_full_unstemmed | Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus |
| title_short | Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus |
| title_sort | mitochondria and oxidative stress as a link between alzheimer s disease and diabetes mellitus |
| topic | neurodegenerative disease diabetes mitochondria oxidative stress neuroinflammation amyloidosis |
| url | https://www.mdpi.com/1422-0067/24/19/14450 |
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