Calcineurin β protects brain after injury by activating the unfolded protein response

Calcineurin β protects brain after injury by activating the unfolded protein response

The Ca2+-dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is unclear. In cultured astrocytes, CNβ expression increased after treatment with a sarco/endoplasmic reticulum Ca2+-ATPase inhibitor, thapsigargin, and with oxy...

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Bibliographic Details
Main Authors: Yanan Chen, Deborah M. Holstein, Sofia Aime, Mariana Bollo, James D. Lechleiter
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Disease
Subjects:
Calcium
Stress
Ischemia
Traumatic brain injury
Endoplasmic reticulum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301449

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