TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether p...
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Bibliographic Details
| Main Authors: |
Fumie Nakasuka,
Sho Tabata,
Takeharu Sakamoto,
Akiyoshi Hirayama,
Hiromichi Ebi,
Tadaaki Yamada,
Ko Umetsu,
Maki Ohishi,
Ayano Ueno,
Hisatsugu Goto,
Masahiro Sugimoto,
Yasuhiko Nishioka,
Yasuhiro Yamada,
Masaru Tomita,
Atsuo T. Sasaki,
Seiji Yano,
Tomoyoshi Soga |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-06-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-021-02323-7
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