TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether p...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02323-7 |
| _version_ | 1818978799555969024 |
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| author | Fumie Nakasuka Sho Tabata Takeharu Sakamoto Akiyoshi Hirayama Hiromichi Ebi Tadaaki Yamada Ko Umetsu Maki Ohishi Ayano Ueno Hisatsugu Goto Masahiro Sugimoto Yasuhiko Nishioka Yasuhiro Yamada Masaru Tomita Atsuo T. Sasaki Seiji Yano Tomoyoshi Soga |
| author_facet | Fumie Nakasuka Sho Tabata Takeharu Sakamoto Akiyoshi Hirayama Hiromichi Ebi Tadaaki Yamada Ko Umetsu Maki Ohishi Ayano Ueno Hisatsugu Goto Masahiro Sugimoto Yasuhiko Nishioka Yasuhiro Yamada Masaru Tomita Atsuo T. Sasaki Seiji Yano Tomoyoshi Soga |
| author_sort | Fumie Nakasuka |
| collection | DOAJ |
| description | Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether providing insights into potential mechanisms of metastasis. |
| first_indexed | 2024-12-20T16:49:23Z |
| format | Article |
| id | doaj.art-27b7bb0504c0470a858988500d6af32e |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-20T16:49:23Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-27b7bb0504c0470a858988500d6af32e2022-12-21T19:32:52ZengNature PortfolioCommunications Biology2399-36422021-06-014111210.1038/s42003-021-02323-7TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancersFumie Nakasuka0Sho Tabata1Takeharu Sakamoto2Akiyoshi Hirayama3Hiromichi Ebi4Tadaaki Yamada5Ko Umetsu6Maki Ohishi7Ayano Ueno8Hisatsugu Goto9Masahiro Sugimoto10Yasuhiko Nishioka11Yasuhiro Yamada12Masaru Tomita13Atsuo T. Sasaki14Seiji Yano15Tomoyoshi Soga16Institute for Advanced Biosciences, Keio UniversityInstitute for Advanced Biosciences, Keio UniversityDivision of Cellular and Molecular Biology, The Institute of Medical Science, The University of TokyoInstitute for Advanced Biosciences, Keio UniversityDivision of Molecular Therapeutics, Aichi Cancer Center Research InstituteDepartment of Pulmonary Medicine, Kyoto Prefectural University of MedicineInstitute for Advanced Biosciences, Keio UniversityInstitute for Advanced Biosciences, Keio UniversityInstitute for Advanced Biosciences, Keio UniversityDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima UniversityInstitute for Advanced Biosciences, Keio UniversityDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima UniversityDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of TokyoInstitute for Advanced Biosciences, Keio UniversityInstitute for Advanced Biosciences, Keio UniversityDepartment of Medical Oncology, Kanazawa University Cancer Research Institute, Kanazawa UniversityInstitute for Advanced Biosciences, Keio UniversityThrough metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether providing insights into potential mechanisms of metastasis.https://doi.org/10.1038/s42003-021-02323-7 |
| spellingShingle | Fumie Nakasuka Sho Tabata Takeharu Sakamoto Akiyoshi Hirayama Hiromichi Ebi Tadaaki Yamada Ko Umetsu Maki Ohishi Ayano Ueno Hisatsugu Goto Masahiro Sugimoto Yasuhiko Nishioka Yasuhiro Yamada Masaru Tomita Atsuo T. Sasaki Seiji Yano Tomoyoshi Soga TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers Communications Biology |
| title | TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers |
| title_full | TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers |
| title_fullStr | TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers |
| title_full_unstemmed | TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers |
| title_short | TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers |
| title_sort | tgf β dependent reprogramming of amino acid metabolism induces epithelial mesenchymal transition in non small cell lung cancers |
| url | https://doi.org/10.1038/s42003-021-02323-7 |
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