Mesenchymal Stem Cells: In Vitro Differentiation among Bone and Cartilage Cell Lineages
Received: 1/May/2007, Accepted: 5/Jul/2007The capacity of mesenchymal stem cells (MSCs) to differentiate amongskeletal cell lineages and to undergo extensive proliferation in vitro rendersthem an appropriate source for cell-replacement therapy to heal defects ofbone and cartilage tissue.It is argued...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2007-01-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | http://celljournal.org/library/upload/article/af_4252724425343744622524352354424382544622librar...53743222225543783343slami.pdf |
| Summary: | Received: 1/May/2007, Accepted: 5/Jul/2007The capacity of mesenchymal stem cells (MSCs) to differentiate amongskeletal cell lineages and to undergo extensive proliferation in vitro rendersthem an appropriate source for cell-replacement therapy to heal defects ofbone and cartilage tissue.It is argued that in bone and cartilage defects,MSCs would better be transplanted as fully-differentiated cells otherwise theymay produce non-specific cells in defect sites. This notion may emphasizethe importance of the studies considering in vitro bone and cartilagedifferentiation of MSCs. Indeed, the capacity of producing osteoblastic andchondrocytic cell lineage is among the earliest differentiation potentials ofMSCs, being reported at first isolation of the cells. Recent studies, howeverindicate that MSCs could differentiate into more cell lineages than expected.The present study provides evidence for, in vitro potential of MSCs todifferentiate into bone and cartilage cell lineages. As an introduction tothe differentiation, the characteristics of MSCs have been described andMSCs differentiation reviewed. The culture condition for bone and cartilagedifferentiation, molecular regulation of the differentiation, signaling pathwayinvolved during the differentiation, and the genes up-regulated upon boneand cartilage differentiation have also been described. |
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| ISSN: | 2228-5806 2228-5814 |