Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival
The discovery of novel and critical genes implicated in malignant development is a topic of high interest in cancer research. Intriguingly, a group of genes named “double-agent” genes were reported to have both oncogenic and tumor-suppressive functions. To date, less than 100 “double-agent” genes ha...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1347 |
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| author | Mingyu Kang Hyeon Ji Kim Tae-Jun Kim Jin-Seok Byun Jae-Ho Lee Deok Heon Lee Wanil Kim Do-Yeon Kim |
| author_facet | Mingyu Kang Hyeon Ji Kim Tae-Jun Kim Jin-Seok Byun Jae-Ho Lee Deok Heon Lee Wanil Kim Do-Yeon Kim |
| author_sort | Mingyu Kang |
| collection | DOAJ |
| description | The discovery of novel and critical genes implicated in malignant development is a topic of high interest in cancer research. Intriguingly, a group of genes named “double-agent” genes were reported to have both oncogenic and tumor-suppressive functions. To date, less than 100 “double-agent” genes have been documented. Fubp1 is a master transcriptional regulator of a subset of genes by interacting with a far upstream element (FUSE). Mounting evidence has collectively demonstrated both the oncogenic and tumor suppressive roles of Fubp1 and the debate regarding its roles in tumorigenesis has been around for several years. Therefore, the detailed molecular mechanisms of Fubp1 need to be determined in each context. In the present study, we showed that the Fubp1 protein level was enriched in the S phase and we identified that Fubp1 deficiency altered cell cycle progression, especially in the S phase, by downregulating the mRNA expression levels of <i>Ccna</i> genes encoding cyclin A. Although this Fubp1-cyclin A axis appears to exist in several types of tumors, Fubp1 showed heterogeneous expression patterns among various cancer tissues, suggesting it exhibits multiple and complicated functions in cancer development. In addition, we showed that Fubp1 deficiency confers survival advantages to cells against metabolic stress and anti-cancer drugs, suggesting that Fubp1 may play both positive and negative roles in malignant development. |
| first_indexed | 2024-03-10T19:32:27Z |
| format | Article |
| id | doaj.art-27ba22c7264a4eab867bc47b62d33e92 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:32:27Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-27ba22c7264a4eab867bc47b62d33e922023-11-20T02:01:00ZengMDPI AGCells2073-44092020-05-0196134710.3390/cells9061347Multiple Functions of Fubp1 in Cell Cycle Progression and Cell SurvivalMingyu Kang0Hyeon Ji Kim1Tae-Jun Kim2Jin-Seok Byun3Jae-Ho Lee4Deok Heon Lee5Wanil Kim6Do-Yeon Kim7Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 700-412, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 700-412, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 700-412, KoreaDepartment of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 700-412, KoreaDepartment of Anatomy, Keimyung University School of Medicine, Daegu 42601, KoreaDepartment of Thoracic and Cardiovascular Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 42601, KoreaDepartment of Cosmetic Science and Technology, College of Bio-industry, Daegu Haany University, Gyeongsan 712-715, KoreaDepartment of Pharmacology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, Daegu 700-412, KoreaThe discovery of novel and critical genes implicated in malignant development is a topic of high interest in cancer research. Intriguingly, a group of genes named “double-agent” genes were reported to have both oncogenic and tumor-suppressive functions. To date, less than 100 “double-agent” genes have been documented. Fubp1 is a master transcriptional regulator of a subset of genes by interacting with a far upstream element (FUSE). Mounting evidence has collectively demonstrated both the oncogenic and tumor suppressive roles of Fubp1 and the debate regarding its roles in tumorigenesis has been around for several years. Therefore, the detailed molecular mechanisms of Fubp1 need to be determined in each context. In the present study, we showed that the Fubp1 protein level was enriched in the S phase and we identified that Fubp1 deficiency altered cell cycle progression, especially in the S phase, by downregulating the mRNA expression levels of <i>Ccna</i> genes encoding cyclin A. Although this Fubp1-cyclin A axis appears to exist in several types of tumors, Fubp1 showed heterogeneous expression patterns among various cancer tissues, suggesting it exhibits multiple and complicated functions in cancer development. In addition, we showed that Fubp1 deficiency confers survival advantages to cells against metabolic stress and anti-cancer drugs, suggesting that Fubp1 may play both positive and negative roles in malignant development.https://www.mdpi.com/2073-4409/9/6/1347Fubp1cell cyclecyclin Acell deathlung cancerdouble-agent |
| spellingShingle | Mingyu Kang Hyeon Ji Kim Tae-Jun Kim Jin-Seok Byun Jae-Ho Lee Deok Heon Lee Wanil Kim Do-Yeon Kim Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival Cells Fubp1 cell cycle cyclin A cell death lung cancer double-agent |
| title | Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival |
| title_full | Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival |
| title_fullStr | Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival |
| title_full_unstemmed | Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival |
| title_short | Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival |
| title_sort | multiple functions of fubp1 in cell cycle progression and cell survival |
| topic | Fubp1 cell cycle cyclin A cell death lung cancer double-agent |
| url | https://www.mdpi.com/2073-4409/9/6/1347 |
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