Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES
To assess the association of environmental chemical factors with osteopenia and/or bone fractures. All data were extracted from the National Health and Nutrition Survey (NHANES) 2017–2018 of American adults aged 20–59 years old; invalid data were excluded based on dual-energy X-ray absorptiometry. F...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/13/3/346 |
| _version_ | 1797610193697112064 |
|---|---|
| author | Run Ling Yuanli Ai Chengzhi Chen Jun Zhang Zhen Zou Shuqun Cheng Chunli Li Xi Li Bin Wang |
| author_facet | Run Ling Yuanli Ai Chengzhi Chen Jun Zhang Zhen Zou Shuqun Cheng Chunli Li Xi Li Bin Wang |
| author_sort | Run Ling |
| collection | DOAJ |
| description | To assess the association of environmental chemical factors with osteopenia and/or bone fractures. All data were extracted from the National Health and Nutrition Survey (NHANES) 2017–2018 of American adults aged 20–59 years old; invalid data were excluded based on dual-energy X-ray absorptiometry. For the ultimate valid data set, multivariate logistic regression models were applied to evaluate the association of environmental chemical factors with osteopenia and bone fractures. The valid dataset was obtained from 2640 individuals, who completed a questionnaire of demographic characteristics. Urinary manganese and monomethylarsonic acid were positively associated with osteopenia in American adults, but not bone fracture. However, several environmental factors (e.g., arsenous acid, arsenocholine, dimethylarsinic acid, and 2-thioxothiazolidine-4-carboxylic acid) did not affect bone mineral density, but were significantly associated with bone fracture. Multiple environmental chemical factors significantly affect bone mass or fracture risk. However, the risk of environmental chemical factors on fractures is independent of osteopenia in US Adults. The influence of environmental chemical factors on bone quality should be considered and monitored. |
| first_indexed | 2024-03-11T06:11:06Z |
| format | Article |
| id | doaj.art-27badbd77d454fc7b429b2a279025dff |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T06:11:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-27badbd77d454fc7b429b2a279025dff2023-11-17T12:36:12ZengMDPI AGMetabolites2218-19892023-02-0113334610.3390/metabo13030346Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANESRun Ling0Yuanli Ai1Chengzhi Chen2Jun Zhang3Zhen Zou4Shuqun Cheng5Chunli Li6Xi Li7Bin Wang8Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Chongqing Medical University, Chongqing 400016, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Chongqing Medical University, Chongqing 400016, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing 400016, ChinaTo assess the association of environmental chemical factors with osteopenia and/or bone fractures. All data were extracted from the National Health and Nutrition Survey (NHANES) 2017–2018 of American adults aged 20–59 years old; invalid data were excluded based on dual-energy X-ray absorptiometry. For the ultimate valid data set, multivariate logistic regression models were applied to evaluate the association of environmental chemical factors with osteopenia and bone fractures. The valid dataset was obtained from 2640 individuals, who completed a questionnaire of demographic characteristics. Urinary manganese and monomethylarsonic acid were positively associated with osteopenia in American adults, but not bone fracture. However, several environmental factors (e.g., arsenous acid, arsenocholine, dimethylarsinic acid, and 2-thioxothiazolidine-4-carboxylic acid) did not affect bone mineral density, but were significantly associated with bone fracture. Multiple environmental chemical factors significantly affect bone mass or fracture risk. However, the risk of environmental chemical factors on fractures is independent of osteopenia in US Adults. The influence of environmental chemical factors on bone quality should be considered and monitored.https://www.mdpi.com/2218-1989/13/3/346environmental chemical factorsbone mineral densityosteopeniabone fractureAmerican adultsNational Health and Nutrition Survey |
| spellingShingle | Run Ling Yuanli Ai Chengzhi Chen Jun Zhang Zhen Zou Shuqun Cheng Chunli Li Xi Li Bin Wang Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES Metabolites environmental chemical factors bone mineral density osteopenia bone fracture American adults National Health and Nutrition Survey |
| title | Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES |
| title_full | Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES |
| title_fullStr | Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES |
| title_full_unstemmed | Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES |
| title_short | Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES |
| title_sort | risk of environmental chemicals on bone fractures is independent of low bone mass in us adults insights from 2017 to 2018 nhanes |
| topic | environmental chemical factors bone mineral density osteopenia bone fracture American adults National Health and Nutrition Survey |
| url | https://www.mdpi.com/2218-1989/13/3/346 |
| work_keys_str_mv | AT runling riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT yuanliai riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT chengzhichen riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT junzhang riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT zhenzou riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT shuquncheng riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT chunlili riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT xili riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes AT binwang riskofenvironmentalchemicalsonbonefracturesisindependentoflowbonemassinusadultsinsightsfrom2017to2018nhanes |