Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
Abstract Introduction- Now a day’s colorectal cancer (CRC) is one of the most deadly cancers in the world. The objective of this investigation was to evaluate the protective effect of gallic acid and pyrogallol in colorectal cancer. Previous reports suggest that there is an association present betwe...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2021-03-01
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| Series: | Iranian Journal of Colorectal Research |
| Subjects: | |
| Online Access: | https://colorectalresearch.sums.ac.ir/article_47450_224f0bde28b2fefd56816886d6dc4b96.pdf |
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| author | Debanjan Mitra Anumita Dey Ishita Biswas Pradeep Das Mohapatra |
| author_facet | Debanjan Mitra Anumita Dey Ishita Biswas Pradeep Das Mohapatra |
| author_sort | Debanjan Mitra |
| collection | DOAJ |
| description | Abstract Introduction- Now a day’s colorectal cancer (CRC) is one of the most deadly cancers in the world. The objective of this investigation was to evaluate the protective effect of gallic acid and pyrogallol in colorectal cancer. Previous reports suggest that there is an association present between some tannase producing bacteria and colorectal cancer. Tannase hydrolyze tannic acid into gallic acid and pyrogallol. Are those compounds have any therapeutic effect on colorectal cancer? This study will help to find those quarries. Methods-The remedial effect of gallic acid and pyrogallol was studied by descriptor properties and molecular docking methods. 100 CRC causing protein structures were docked in this investigation. Results- Lipinski Rule of Five and other descriptor properties of those compounds have showed their nontoxic and therapeutic nature. Molecular docking studies have showed highest score -38.22 KJ/Mol with gallic acid and -33.6 KJ/Mol with pyrogallol. Conclusion- This is the first report on docking investigation of these large numbers of protein. The findings of this research concluded that gallic acid and pyrogallol have a protective effect in colorectal cancer by stopping the effect of those CRC causing protein. |
| first_indexed | 2024-04-11T09:21:11Z |
| format | Article |
| id | doaj.art-27bc9541dfa84582b575c4957aa5f52e |
| institution | Directory Open Access Journal |
| issn | 2783-2430 |
| language | English |
| last_indexed | 2024-04-11T09:21:11Z |
| publishDate | 2021-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Colorectal Research |
| spelling | doaj.art-27bc9541dfa84582b575c4957aa5f52e2022-12-22T04:32:10ZengShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24302021-03-0191323910.30476/acrr.2021.89642.108047450Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and PyrogallolDebanjan Mitra0Anumita Dey1Ishita Biswas2Pradeep Das Mohapatra3Department of Microbiology, Raiganj University, Raiganj, WB, IndiaDepartment of Microbiology, Raiganj University, Raiganj, WB, IndiaDepartment of Microbiology, Raiganj University, Raiganj, WB, IndiaDepartment of Microbiology, Raiganj University, Raiganj, WB, IndiaAbstract Introduction- Now a day’s colorectal cancer (CRC) is one of the most deadly cancers in the world. The objective of this investigation was to evaluate the protective effect of gallic acid and pyrogallol in colorectal cancer. Previous reports suggest that there is an association present between some tannase producing bacteria and colorectal cancer. Tannase hydrolyze tannic acid into gallic acid and pyrogallol. Are those compounds have any therapeutic effect on colorectal cancer? This study will help to find those quarries. Methods-The remedial effect of gallic acid and pyrogallol was studied by descriptor properties and molecular docking methods. 100 CRC causing protein structures were docked in this investigation. Results- Lipinski Rule of Five and other descriptor properties of those compounds have showed their nontoxic and therapeutic nature. Molecular docking studies have showed highest score -38.22 KJ/Mol with gallic acid and -33.6 KJ/Mol with pyrogallol. Conclusion- This is the first report on docking investigation of these large numbers of protein. The findings of this research concluded that gallic acid and pyrogallol have a protective effect in colorectal cancer by stopping the effect of those CRC causing protein.https://colorectalresearch.sums.ac.ir/article_47450_224f0bde28b2fefd56816886d6dc4b96.pdfcolorectal cancerdescriptor propertiesmolecular dockingbinding energy |
| spellingShingle | Debanjan Mitra Anumita Dey Ishita Biswas Pradeep Das Mohapatra Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol Iranian Journal of Colorectal Research colorectal cancer descriptor properties molecular docking binding energy |
| title | Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol |
| title_full | Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol |
| title_fullStr | Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol |
| title_full_unstemmed | Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol |
| title_short | Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol |
| title_sort | bioactive compounds as a potential inhibitor of colorectal cancer an insilico study of gallic acid and pyrogallol |
| topic | colorectal cancer descriptor properties molecular docking binding energy |
| url | https://colorectalresearch.sums.ac.ir/article_47450_224f0bde28b2fefd56816886d6dc4b96.pdf |
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