Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases
The aorta is the largest artery in the body, so any diseases or conditions which could cause damage to the aorta would put patients at considerable and life-threatening risk. In the management of aortic diseases, the major treatments include drug therapy, endovascular treatment, and surgical treatme...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.583879/full |
| _version_ | 1819052726905995264 |
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| author | Shichao Zhu Shichao Zhu Kai Zhu Kai Zhu Jun Li Jun Li Hao Lai Hao Lai Chunsheng Wang Chunsheng Wang |
| author_facet | Shichao Zhu Shichao Zhu Kai Zhu Kai Zhu Jun Li Jun Li Hao Lai Hao Lai Chunsheng Wang Chunsheng Wang |
| author_sort | Shichao Zhu |
| collection | DOAJ |
| description | The aorta is the largest artery in the body, so any diseases or conditions which could cause damage to the aorta would put patients at considerable and life-threatening risk. In the management of aortic diseases, the major treatments include drug therapy, endovascular treatment, and surgical treatment, which are of great danger or with a poor prognosis. The delivery of nano-biomaterials provides a potential development trend and an emerging field where we could monitor patients’ conditions and responses to the nanotherapeutics. One of the putative applications of nanotechnology is ultrasensitive monitoring of cardiovascular markers by detecting and identifying aneurysms. Moreover, the use of nanosystems for targeted drug delivery can minimize the systemic side effects and enhance drug positioning and efficacy compared to conventional drug therapies. This review shows some examples of utilizing nano-biomaterials in in vitro organ and cell culture experiments and explains some developing technologies in delivering and monitoring regenerative therapeutics. |
| first_indexed | 2024-12-21T12:24:25Z |
| format | Article |
| id | doaj.art-27bd79cf160a4afab405e7f44b0c15fc |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-21T12:24:25Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-27bd79cf160a4afab405e7f44b0c15fc2022-12-21T19:04:13ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-11-01810.3389/fbioe.2020.583879583879Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic DiseasesShichao Zhu0Shichao Zhu1Kai Zhu2Kai Zhu3Jun Li4Jun Li5Hao Lai6Hao Lai7Chunsheng Wang8Chunsheng Wang9Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Diseases, Shanghai, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Diseases, Shanghai, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Diseases, Shanghai, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Diseases, Shanghai, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Diseases, Shanghai, ChinaThe aorta is the largest artery in the body, so any diseases or conditions which could cause damage to the aorta would put patients at considerable and life-threatening risk. In the management of aortic diseases, the major treatments include drug therapy, endovascular treatment, and surgical treatment, which are of great danger or with a poor prognosis. The delivery of nano-biomaterials provides a potential development trend and an emerging field where we could monitor patients’ conditions and responses to the nanotherapeutics. One of the putative applications of nanotechnology is ultrasensitive monitoring of cardiovascular markers by detecting and identifying aneurysms. Moreover, the use of nanosystems for targeted drug delivery can minimize the systemic side effects and enhance drug positioning and efficacy compared to conventional drug therapies. This review shows some examples of utilizing nano-biomaterials in in vitro organ and cell culture experiments and explains some developing technologies in delivering and monitoring regenerative therapeutics.https://www.frontiersin.org/articles/10.3389/fbioe.2020.583879/fullnano-biomaterialsaortic diseasestherapeuticsdrug deliveryregeneration |
| spellingShingle | Shichao Zhu Shichao Zhu Kai Zhu Kai Zhu Jun Li Jun Li Hao Lai Hao Lai Chunsheng Wang Chunsheng Wang Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases Frontiers in Bioengineering and Biotechnology nano-biomaterials aortic diseases therapeutics drug delivery regeneration |
| title | Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases |
| title_full | Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases |
| title_fullStr | Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases |
| title_full_unstemmed | Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases |
| title_short | Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases |
| title_sort | nano biomaterials for the delivery of therapeutic and monitoring cues for aortic diseases |
| topic | nano-biomaterials aortic diseases therapeutics drug delivery regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.583879/full |
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