Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem
A biofilm is a population of sessile microorganisms that has a distinct organized structure and characteristics like channels and projections. Good oral hygiene and reduction in the prevalence of periodontal diseases arise from minimal biofilm accumulation in the mouth, however, studies focusing on...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223007564 |
| _version_ | 1797801826687385600 |
|---|---|
| author | Antarikshya Das Swadheena Patro Faizan Zarreen Simnani Dibyangshee Singh Adrija Sinha Khushbu Kumari Patnala Vedika Rao Sarita Singh Nagendra Kumar Kaushik Pritam Kumar Panda Mrutyunjay Suar Suresh K. Verma |
| author_facet | Antarikshya Das Swadheena Patro Faizan Zarreen Simnani Dibyangshee Singh Adrija Sinha Khushbu Kumari Patnala Vedika Rao Sarita Singh Nagendra Kumar Kaushik Pritam Kumar Panda Mrutyunjay Suar Suresh K. Verma |
| author_sort | Antarikshya Das |
| collection | DOAJ |
| description | A biofilm is a population of sessile microorganisms that has a distinct organized structure and characteristics like channels and projections. Good oral hygiene and reduction in the prevalence of periodontal diseases arise from minimal biofilm accumulation in the mouth, however, studies focusing on modifying the ecology of oral biofilms have not yet been consistently effective. The self-produced matrix of extracellular polymeric substances and greater antibiotic resistance make it difficult to target and eliminate biofilm infections, which lead to serious clinical consequences that are often lethal. Therefore, a better understanding is required to target and modify the ecology of biofilms in order to eradicate the infection, not only in instances of oral disorders but also in terms of nosocomial infections. The review focuses on several biofilm ecology modifiers to prevent biofilm infections, as well as the involvement of biofilm in antibiotic resistance, implants or in-dwelling device contamination, dental caries, and other periodontal disorders. It also discusses recent advances in nanotechnology that may lead to novel strategies for preventing and treating infections caused by biofilms as well as a novel outlook to infection control. |
| first_indexed | 2024-03-13T04:56:27Z |
| format | Article |
| id | doaj.art-27bf291139e84aafac4067a9ae28a815 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:27Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-27bf291139e84aafac4067a9ae28a8152023-06-18T05:00:52ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114966Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystemAntarikshya Das0Swadheena Patro1Faizan Zarreen Simnani2Dibyangshee Singh3Adrija Sinha4Khushbu Kumari5Patnala Vedika Rao6Sarita Singh7Nagendra Kumar Kaushik8Pritam Kumar Panda9Mrutyunjay Suar10Suresh K. Verma11KIIT School of Dental Sciences, KIIT University, Bhubaneswar 751024, Odisha, IndiaKIIT School of Dental Sciences, KIIT University, Bhubaneswar 751024, Odisha, India; Corresponding authors.KIIT School of Biotechnology, KIIT University, Bhubaneswar 751024, Odisha, IndiaKIIT School of Biotechnology, KIIT University, Bhubaneswar 751024, Odisha, IndiaKIIT School of Biotechnology, KIIT University, Bhubaneswar 751024, Odisha, IndiaKIIT School of Dental Sciences, KIIT University, Bhubaneswar 751024, Odisha, IndiaKIIT School of Medical Sciences, KIIT University, Bhubaneswar 751024, Odisha, IndiaBVG Life Sciences Limited, Sagar Complex, Old Pune-Mumbai Road, Chinchwad, Pune 411034, IndiaPlasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, 01897 Seoul, Republic of Korea; Corresponding authors.Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden; Corresponding authors.KIIT School of Dental Sciences, KIIT University, Bhubaneswar 751024, Odisha, India; Corresponding authors.KIIT School of Dental Sciences, KIIT University, Bhubaneswar 751024, Odisha, India; Corresponding authors.A biofilm is a population of sessile microorganisms that has a distinct organized structure and characteristics like channels and projections. Good oral hygiene and reduction in the prevalence of periodontal diseases arise from minimal biofilm accumulation in the mouth, however, studies focusing on modifying the ecology of oral biofilms have not yet been consistently effective. The self-produced matrix of extracellular polymeric substances and greater antibiotic resistance make it difficult to target and eliminate biofilm infections, which lead to serious clinical consequences that are often lethal. Therefore, a better understanding is required to target and modify the ecology of biofilms in order to eradicate the infection, not only in instances of oral disorders but also in terms of nosocomial infections. The review focuses on several biofilm ecology modifiers to prevent biofilm infections, as well as the involvement of biofilm in antibiotic resistance, implants or in-dwelling device contamination, dental caries, and other periodontal disorders. It also discusses recent advances in nanotechnology that may lead to novel strategies for preventing and treating infections caused by biofilms as well as a novel outlook to infection control.http://www.sciencedirect.com/science/article/pii/S0753332223007564BiofilmOral BiomeAntibiotic resistancePeriodontal disorders |
| spellingShingle | Antarikshya Das Swadheena Patro Faizan Zarreen Simnani Dibyangshee Singh Adrija Sinha Khushbu Kumari Patnala Vedika Rao Sarita Singh Nagendra Kumar Kaushik Pritam Kumar Panda Mrutyunjay Suar Suresh K. Verma Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem Biomedicine & Pharmacotherapy Biofilm Oral Biome Antibiotic resistance Periodontal disorders |
| title | Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem |
| title_full | Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem |
| title_fullStr | Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem |
| title_full_unstemmed | Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem |
| title_short | Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem |
| title_sort | biofilm modifiers the disparity in paradigm of oral biofilm ecosystem |
| topic | Biofilm Oral Biome Antibiotic resistance Periodontal disorders |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223007564 |
| work_keys_str_mv | AT antarikshyadas biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT swadheenapatro biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT faizanzarreensimnani biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT dibyangsheesingh biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT adrijasinha biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT khushbukumari biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT patnalavedikarao biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT saritasingh biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT nagendrakumarkaushik biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT pritamkumarpanda biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT mrutyunjaysuar biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem AT sureshkverma biofilmmodifiersthedisparityinparadigmoforalbiofilmecosystem |