<i>Drosophila</i> Nesprin-1 Isoforms Differentially Contribute to Muscle Function

<i>Drosophila</i> Nesprin-1 Isoforms Differentially Contribute to Muscle Function

Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning. Furthermore, Nesprin-1 mutations are associated with muscul...

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Bibliographic Details
Main Authors: Alexandre Rey, Laurent Schaeffer, Bénédicte Durand, Véronique Morel
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
Nesprin-1
Msp300
<i>Drosophila</i>
myofibrils
desmin
isoforms
Online Access:https://www.mdpi.com/2073-4409/10/11/3061

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