Association of paternal age at birth and the risk of breast cancer in offspring: a case control study
<p>Abstract</p> <p>Background</p> <p>Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate <it>in utero </it>exposure to pregnancy hormones in the offspring. To evaluate the association between paternal a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-10-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/5/143 |
| _version_ | 1818060894320459776 |
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| author | Yoo Keun-Young Ahn Sei-Hyun Noh Dong-Young Park Sue Lee Kyoung-Mu Choi Ji-Yeob Kang Daehee |
| author_facet | Yoo Keun-Young Ahn Sei-Hyun Noh Dong-Young Park Sue Lee Kyoung-Mu Choi Ji-Yeob Kang Daehee |
| author_sort | Yoo Keun-Young |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate <it>in utero </it>exposure to pregnancy hormones in the offspring. To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea.</p> <p>Methods</p> <p>Histologically confirmed breast cancer cases (n = 1,011) and controls (n = 1,011) with no present or previous history of cancer, matched on year of birth and menopausal status, were selected from several teaching hospitals and community in Seoul during 1995–2003. Information on paternal and maternal ages and other factors was collected by interviewed questionnaire. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression model adjusting for family history of breast cancer in 1<sup>st </sup>or 2<sup>nd </sup>degree relatives, and lifetime estrogen exposure duration.</p> <p>Results</p> <p>The risk of breast cancer significantly increased as the paternal age increased (p for trend = 0.025). The association was stronger after controlling for maternal age; women whose fathers were aged ≥40 years at their birth had 1.6-fold increased risk of breast cancer compared with fathers aged <30 years. This association was profound in breast cancer cases in premenopausal women (OR = 1.9, 95% CI = 1.12–3.26, for paternal aged ≥40 vs. <30) (p for trend = 0.031). Although the risk of breast cancer increased as maternal age increased up to the intermediate, and then reduced; the risks in women whose mother were aged 25–29, 30–34, and ≥35 yrs at birth compared to women whose mothers were aged <25 years, were 1.2, 1.4, and 0.8, respectively, the trend was not significant (p for trend = 0.998).</p> <p>Conclusion</p> <p>These findings suggest that older paternal age increases the risk of breast cancer in their female offspring.</p> |
| first_indexed | 2024-12-10T13:39:40Z |
| format | Article |
| id | doaj.art-27bf8661e91c4634b07f711b18405e5b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-10T13:39:40Z |
| publishDate | 2005-10-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj.art-27bf8661e91c4634b07f711b18405e5b2022-12-22T01:46:42ZengBMCBMC Cancer1471-24072005-10-015114310.1186/1471-2407-5-143Association of paternal age at birth and the risk of breast cancer in offspring: a case control studyYoo Keun-YoungAhn Sei-HyunNoh Dong-YoungPark SueLee Kyoung-MuChoi Ji-YeobKang Daehee<p>Abstract</p> <p>Background</p> <p>Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate <it>in utero </it>exposure to pregnancy hormones in the offspring. To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea.</p> <p>Methods</p> <p>Histologically confirmed breast cancer cases (n = 1,011) and controls (n = 1,011) with no present or previous history of cancer, matched on year of birth and menopausal status, were selected from several teaching hospitals and community in Seoul during 1995–2003. Information on paternal and maternal ages and other factors was collected by interviewed questionnaire. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression model adjusting for family history of breast cancer in 1<sup>st </sup>or 2<sup>nd </sup>degree relatives, and lifetime estrogen exposure duration.</p> <p>Results</p> <p>The risk of breast cancer significantly increased as the paternal age increased (p for trend = 0.025). The association was stronger after controlling for maternal age; women whose fathers were aged ≥40 years at their birth had 1.6-fold increased risk of breast cancer compared with fathers aged <30 years. This association was profound in breast cancer cases in premenopausal women (OR = 1.9, 95% CI = 1.12–3.26, for paternal aged ≥40 vs. <30) (p for trend = 0.031). Although the risk of breast cancer increased as maternal age increased up to the intermediate, and then reduced; the risks in women whose mother were aged 25–29, 30–34, and ≥35 yrs at birth compared to women whose mothers were aged <25 years, were 1.2, 1.4, and 0.8, respectively, the trend was not significant (p for trend = 0.998).</p> <p>Conclusion</p> <p>These findings suggest that older paternal age increases the risk of breast cancer in their female offspring.</p>http://www.biomedcentral.com/1471-2407/5/143 |
| spellingShingle | Yoo Keun-Young Ahn Sei-Hyun Noh Dong-Young Park Sue Lee Kyoung-Mu Choi Ji-Yeob Kang Daehee Association of paternal age at birth and the risk of breast cancer in offspring: a case control study BMC Cancer |
| title | Association of paternal age at birth and the risk of breast cancer in offspring: a case control study |
| title_full | Association of paternal age at birth and the risk of breast cancer in offspring: a case control study |
| title_fullStr | Association of paternal age at birth and the risk of breast cancer in offspring: a case control study |
| title_full_unstemmed | Association of paternal age at birth and the risk of breast cancer in offspring: a case control study |
| title_short | Association of paternal age at birth and the risk of breast cancer in offspring: a case control study |
| title_sort | association of paternal age at birth and the risk of breast cancer in offspring a case control study |
| url | http://www.biomedcentral.com/1471-2407/5/143 |
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