The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review
Introduction: Nasopharyngeal carcinoma (NPC) is a rare and aggressive head and neck squamous cell carcinoma worldwide.Tumor-infiltrating lymphocytes (TILs) have been studied and reported to be effective targets of drugs on cancer and were related to the prognostic value.The aim of the study was to l...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2021-07-01
|
| Series: | Iranian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | https://ijorl.mums.ac.ir/article_18294_51fa59ebb5b1e3664b37acc493a061f8.pdf |
| _version_ | 1818366375002898432 |
|---|---|
| author | Jethro Budiman Awal Prasetyo Udadi Sadhana |
| author_facet | Jethro Budiman Awal Prasetyo Udadi Sadhana |
| author_sort | Jethro Budiman |
| collection | DOAJ |
| description | Introduction: Nasopharyngeal carcinoma (NPC) is a rare and aggressive head and neck squamous cell carcinoma worldwide.Tumor-infiltrating lymphocytes (TILs) have been studied and reported to be effective targets of drugs on cancer and were related to the prognostic value.The aim of the study was to look systematically into the current literature and carefully analyze the results to explore the relationship of TILs and NPC. Materials and Methods: Three independent reviewers conducted the literature search, searching for articles published in January 2000-January 2020 and fulfilling inclusion and exclusion criteria. The lead author independently assessed the risk of bias of each of the included studies and discussed their assessments with the other two authors to achieve consensus. Of the 1233 articles identified in database searching, 12 articles met the criteria for this review. Results: The majority of the study designs were cohort (9 of 12 studies). Most of the studies discussed the prognostic significance of TILs in NPC (nine studies), two studies reported the expanded TILs for the treatment of NPC, and one study reported TILs based on one gene expression. Conclusion: TILs in NPC are related to the prognostic factor and development of the immunotherapy. High TILs were associated with better outcome and survival rate; and TILs have been claimed to reflect an effective anti-tumor immune response, immune response inducer, delayed tumor progression, and improving the cancer-immune microenvironment. The understanding of TILs in NPC based on gene expression becomes important information to learn more about the relationship of TILs and NPC. |
| first_indexed | 2024-12-13T22:35:09Z |
| format | Article |
| id | doaj.art-27c2d1f8c2de47d6b947fcc38b68b616 |
| institution | Directory Open Access Journal |
| issn | 2251-7251 2251-726X |
| language | English |
| last_indexed | 2024-12-13T22:35:09Z |
| publishDate | 2021-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Otorhinolaryngology |
| spelling | doaj.art-27c2d1f8c2de47d6b947fcc38b68b6162022-12-21T23:28:59ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2021-07-0133419120010.22038/ijorl.2021.51405.273318294The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic ReviewJethro Budiman0Awal Prasetyo1Udadi Sadhana2Department of Biomedical Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.Emergency Unit of Panti Wilasa Citarum Hospital, Semarang, Indonesia.Department of Anatomic Pathology, Faculty of Medicine, Diponegoro University - dr. Kariadi Hospital, Semarang, Indonesia.Introduction: Nasopharyngeal carcinoma (NPC) is a rare and aggressive head and neck squamous cell carcinoma worldwide.Tumor-infiltrating lymphocytes (TILs) have been studied and reported to be effective targets of drugs on cancer and were related to the prognostic value.The aim of the study was to look systematically into the current literature and carefully analyze the results to explore the relationship of TILs and NPC. Materials and Methods: Three independent reviewers conducted the literature search, searching for articles published in January 2000-January 2020 and fulfilling inclusion and exclusion criteria. The lead author independently assessed the risk of bias of each of the included studies and discussed their assessments with the other two authors to achieve consensus. Of the 1233 articles identified in database searching, 12 articles met the criteria for this review. Results: The majority of the study designs were cohort (9 of 12 studies). Most of the studies discussed the prognostic significance of TILs in NPC (nine studies), two studies reported the expanded TILs for the treatment of NPC, and one study reported TILs based on one gene expression. Conclusion: TILs in NPC are related to the prognostic factor and development of the immunotherapy. High TILs were associated with better outcome and survival rate; and TILs have been claimed to reflect an effective anti-tumor immune response, immune response inducer, delayed tumor progression, and improving the cancer-immune microenvironment. The understanding of TILs in NPC based on gene expression becomes important information to learn more about the relationship of TILs and NPC.https://ijorl.mums.ac.ir/article_18294_51fa59ebb5b1e3664b37acc493a061f8.pdfimmunologynasopharyngeal carcinomatumor-infiltrating lymphocytes |
| spellingShingle | Jethro Budiman Awal Prasetyo Udadi Sadhana The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review Iranian Journal of Otorhinolaryngology immunology nasopharyngeal carcinoma tumor-infiltrating lymphocytes |
| title | The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review |
| title_full | The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review |
| title_fullStr | The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review |
| title_full_unstemmed | The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review |
| title_short | The Relationship between Tumor-infiltrating Lymphocytes (TILs) and Nasopharyngeal Carcinoma (NPC):A Systematic Review |
| title_sort | relationship between tumor infiltrating lymphocytes tils and nasopharyngeal carcinoma npc a systematic review |
| topic | immunology nasopharyngeal carcinoma tumor-infiltrating lymphocytes |
| url | https://ijorl.mums.ac.ir/article_18294_51fa59ebb5b1e3664b37acc493a061f8.pdf |
| work_keys_str_mv | AT jethrobudiman therelationshipbetweentumorinfiltratinglymphocytestilsandnasopharyngealcarcinomanpcasystematicreview AT awalprasetyo therelationshipbetweentumorinfiltratinglymphocytestilsandnasopharyngealcarcinomanpcasystematicreview AT udadisadhana therelationshipbetweentumorinfiltratinglymphocytestilsandnasopharyngealcarcinomanpcasystematicreview AT jethrobudiman relationshipbetweentumorinfiltratinglymphocytestilsandnasopharyngealcarcinomanpcasystematicreview AT awalprasetyo relationshipbetweentumorinfiltratinglymphocytestilsandnasopharyngealcarcinomanpcasystematicreview AT udadisadhana relationshipbetweentumorinfiltratinglymphocytestilsandnasopharyngealcarcinomanpcasystematicreview |