Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population.
Obesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4438865?pdf=render |
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| author | Isabel Ponce-Garcia Marta Simarro-Rueda Julio Antonio Carbayo-Herencia Juan Antonio Divisón-Garrote Luis Miguel Artigao-Ródenas Francisco Botella-Romero Antonio Palazón-Bru Damian Robert James Martínez-St John Vicente Francisco Gil-Guillén Group of Vascular Diseases from Albacete |
| author_facet | Isabel Ponce-Garcia Marta Simarro-Rueda Julio Antonio Carbayo-Herencia Juan Antonio Divisón-Garrote Luis Miguel Artigao-Ródenas Francisco Botella-Romero Antonio Palazón-Bru Damian Robert James Martínez-St John Vicente Francisco Gil-Guillén Group of Vascular Diseases from Albacete |
| author_sort | Isabel Ponce-Garcia |
| collection | DOAJ |
| description | Obesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non-fatal first cardiovascular event) in a general population sample from the south-east of Spain.This prospective cohort study used stratified and randomized two-stage sampling. Obesity [body mass index (BMI) ≥ 30 kg/m(2)] as a predictive variable of mortality and cardiovascular events was assessed after controlling for age, sex, cardiovascular disease history, high blood pressure, diabetes mellitus, hypercholesterolemia, high-density lipoprotein/triglycerides ratio, total cholesterol and smoking with the Cox regression model.The mean follow-up time of the 1,248 participants was 10.6 years. The incidence of all-cause mortality during this period was 97 deaths for every 10,000 person/years (95% CI: 80-113) and the incidence of all-cause mortality+cardiovascular morbidity was 143 cases for every 10,000 person/years (95% CI: 124-163). A BMI ≥ 35 kg/m(2) yielded a hazard ratio for all-cause mortality of 1.94 (95% CI: 1.11-3.42) in comparison to non-obese subjects (BMI <30 kg/m(2)). For the combination of cardiovascular morbidity plus all-cause mortality, a BMI ≥ 35 kg/m(2) had a hazard ratio of 1.84 (95% CI: 1.15-2.93) compared to non-obese subjects.A BMI ≥ 35 kg/m(2) is an important predictor of both overall mortality and of the combination of cardiovascular morbidity plus all-cause mortality. |
| first_indexed | 2024-12-12T16:05:51Z |
| format | Article |
| id | doaj.art-27c45bcc77244716aac27403e8be692f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T16:05:51Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-27c45bcc77244716aac27403e8be692f2022-12-22T00:19:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012736910.1371/journal.pone.0127369Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population.Isabel Ponce-GarciaMarta Simarro-RuedaJulio Antonio Carbayo-HerenciaJuan Antonio Divisón-GarroteLuis Miguel Artigao-RódenasFrancisco Botella-RomeroAntonio Palazón-BruDamian Robert James Martínez-St JohnVicente Francisco Gil-GuillénGroup of Vascular Diseases from AlbaceteObesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non-fatal first cardiovascular event) in a general population sample from the south-east of Spain.This prospective cohort study used stratified and randomized two-stage sampling. Obesity [body mass index (BMI) ≥ 30 kg/m(2)] as a predictive variable of mortality and cardiovascular events was assessed after controlling for age, sex, cardiovascular disease history, high blood pressure, diabetes mellitus, hypercholesterolemia, high-density lipoprotein/triglycerides ratio, total cholesterol and smoking with the Cox regression model.The mean follow-up time of the 1,248 participants was 10.6 years. The incidence of all-cause mortality during this period was 97 deaths for every 10,000 person/years (95% CI: 80-113) and the incidence of all-cause mortality+cardiovascular morbidity was 143 cases for every 10,000 person/years (95% CI: 124-163). A BMI ≥ 35 kg/m(2) yielded a hazard ratio for all-cause mortality of 1.94 (95% CI: 1.11-3.42) in comparison to non-obese subjects (BMI <30 kg/m(2)). For the combination of cardiovascular morbidity plus all-cause mortality, a BMI ≥ 35 kg/m(2) had a hazard ratio of 1.84 (95% CI: 1.15-2.93) compared to non-obese subjects.A BMI ≥ 35 kg/m(2) is an important predictor of both overall mortality and of the combination of cardiovascular morbidity plus all-cause mortality.http://europepmc.org/articles/PMC4438865?pdf=render |
| spellingShingle | Isabel Ponce-Garcia Marta Simarro-Rueda Julio Antonio Carbayo-Herencia Juan Antonio Divisón-Garrote Luis Miguel Artigao-Ródenas Francisco Botella-Romero Antonio Palazón-Bru Damian Robert James Martínez-St John Vicente Francisco Gil-Guillén Group of Vascular Diseases from Albacete Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population. PLoS ONE |
| title | Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population. |
| title_full | Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population. |
| title_fullStr | Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population. |
| title_full_unstemmed | Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population. |
| title_short | Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population. |
| title_sort | prognostic value of obesity on both overall mortality and cardiovascular disease in the general population |
| url | http://europepmc.org/articles/PMC4438865?pdf=render |
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