Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering
Electrospun nanofibers are promising bone tissue scaffolds that support bone healing due to the body’s structural similarity to the extracellular matrix (ECM). However, the insufficient mechanical properties often limit their potential in bone tissue regeneration. Cross-linking agents that chemicall...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/10/5444 |
| _version_ | 1797499209030565888 |
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| author | Dong-Jin Lim |
| author_facet | Dong-Jin Lim |
| author_sort | Dong-Jin Lim |
| collection | DOAJ |
| description | Electrospun nanofibers are promising bone tissue scaffolds that support bone healing due to the body’s structural similarity to the extracellular matrix (ECM). However, the insufficient mechanical properties often limit their potential in bone tissue regeneration. Cross-linking agents that chemically interconnect as-spun electrospun nanofibers are a simple but effective strategy for improving electrospun nanofibers’ mechanical, biological, and degradation properties. To improve the mechanical characteristic of the nanofibrous bone scaffolds, two of the most common types of cross-linking agents are used to chemically crosslink electrospun nanofibers: synthetic and natural. Glutaraldehyde (GTA) is a typical synthetic agent for electrospun nanofibers, while genipin (GP) is a natural cross-linking agent isolated from gardenia fruit extracts. GP has gradually gained attention since GP has superior biocompatibility to synthetic ones. In recent studies, much more progress has been made in utilizing crosslinking strategies, including citric acid (CA), a natural cross-linking agent. This review summarizes both cross-linking agents commonly used to improve electrospun-based scaffolds in bone tissue engineering, explains recent progress, and attempts to expand the potential of this straightforward method for electrospinning-based bone tissue engineering. |
| first_indexed | 2024-03-10T03:45:09Z |
| format | Article |
| id | doaj.art-27c5408f293d442098f60411bc3e6c89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:45:09Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-27c5408f293d442098f60411bc3e6c892023-11-23T11:22:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310544410.3390/ijms23105444Cross-Linking Agents for Electrospinning-Based Bone Tissue EngineeringDong-Jin Lim0Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USAElectrospun nanofibers are promising bone tissue scaffolds that support bone healing due to the body’s structural similarity to the extracellular matrix (ECM). However, the insufficient mechanical properties often limit their potential in bone tissue regeneration. Cross-linking agents that chemically interconnect as-spun electrospun nanofibers are a simple but effective strategy for improving electrospun nanofibers’ mechanical, biological, and degradation properties. To improve the mechanical characteristic of the nanofibrous bone scaffolds, two of the most common types of cross-linking agents are used to chemically crosslink electrospun nanofibers: synthetic and natural. Glutaraldehyde (GTA) is a typical synthetic agent for electrospun nanofibers, while genipin (GP) is a natural cross-linking agent isolated from gardenia fruit extracts. GP has gradually gained attention since GP has superior biocompatibility to synthetic ones. In recent studies, much more progress has been made in utilizing crosslinking strategies, including citric acid (CA), a natural cross-linking agent. This review summarizes both cross-linking agents commonly used to improve electrospun-based scaffolds in bone tissue engineering, explains recent progress, and attempts to expand the potential of this straightforward method for electrospinning-based bone tissue engineering.https://www.mdpi.com/1422-0067/23/10/5444electrospinningcross-linking agentsglutaraldehyde1-ethyl-3-(3-dimethylaminopropyl)-carbodiimidegenipincitric acid |
| spellingShingle | Dong-Jin Lim Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering International Journal of Molecular Sciences electrospinning cross-linking agents glutaraldehyde 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide genipin citric acid |
| title | Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering |
| title_full | Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering |
| title_fullStr | Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering |
| title_full_unstemmed | Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering |
| title_short | Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering |
| title_sort | cross linking agents for electrospinning based bone tissue engineering |
| topic | electrospinning cross-linking agents glutaraldehyde 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide genipin citric acid |
| url | https://www.mdpi.com/1422-0067/23/10/5444 |
| work_keys_str_mv | AT dongjinlim crosslinkingagentsforelectrospinningbasedbonetissueengineering |