Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report
Antiphospholipid syndrome is an autoimmune disorder characterized by arterial and venous thrombosis and recurrent spontaneous abortions due to the persistent presence of antiphospholipid antibodies. Probable Catastrophic antiphospholipid (Catastrophic antiphospholipid-like syndrome) is a life-threat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-12-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X231220803 |
| _version_ | 1797383439831269376 |
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| author | Seyed M Nahidi Yash Garg Devi S Mahadeo Manjari Sharma Cesar Acosta Karthik Seetharam Mukosolu F Obi |
| author_facet | Seyed M Nahidi Yash Garg Devi S Mahadeo Manjari Sharma Cesar Acosta Karthik Seetharam Mukosolu F Obi |
| author_sort | Seyed M Nahidi |
| collection | DOAJ |
| description | Antiphospholipid syndrome is an autoimmune disorder characterized by arterial and venous thrombosis and recurrent spontaneous abortions due to the persistent presence of antiphospholipid antibodies. Probable Catastrophic antiphospholipid (Catastrophic antiphospholipid-like syndrome) is a life-threatening presentation of antiphospholipid syndrome which manifests as intravascular thrombosis, leading to rapid onset of symptoms and involvement of multiple organ systems. We present a case of a 28-year-old woman with a history of polyglandular autoimmune syndrome, systemic lupus erythematosus, provoked bilateral deep vein thrombosis in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection 2 years prior, and hypothyroidism who presents with a cardiac arrest in the setting of an acute ST-elevation myocardial infarction with thromboembolic occlusion of two coronary arteries simultaneously in the setting of noncompliance with anticoagulation for the past 1 week. Her presentation was further complicated by acute hypoxic respiratory failure due to diffuse alveolar hemorrhage during the hospital course with progressive multiorgan failure and eventual death. Catastrophic antiphospholipid is associated with high morbidity and mortality, thus a timely diagnosis and multidisciplinary approach to management is needed for evaluation and management. |
| first_indexed | 2024-03-08T21:21:01Z |
| format | Article |
| id | doaj.art-27c6664724af47919da835f28ecb9f27 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-03-08T21:21:01Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-27c6664724af47919da835f28ecb9f272023-12-21T10:03:54ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2023-12-011110.1177/2050313X231220803Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case reportSeyed M Nahidi0Yash Garg1Devi S Mahadeo2Manjari Sharma3Cesar Acosta4Karthik Seetharam5Mukosolu F Obi6Internal Medicine Resident at Wyckoff Heights Medical Center, Brooklyn, NY, USAInternal Medicine Resident at Wyckoff Heights Medical Center, Brooklyn, NY, USASt George’s University, Grenada, West IndiesInternal Medicine Resident at Wyckoff Heights Medical Center, Brooklyn, NY, USAInternal Medicine Resident at Wyckoff Heights Medical Center, Brooklyn, NY, USAInternal Medicine Resident at Wyckoff Heights Medical Center, Brooklyn, NY, USAInternal Medicine Resident at Wyckoff Heights Medical Center, Brooklyn, NY, USAAntiphospholipid syndrome is an autoimmune disorder characterized by arterial and venous thrombosis and recurrent spontaneous abortions due to the persistent presence of antiphospholipid antibodies. Probable Catastrophic antiphospholipid (Catastrophic antiphospholipid-like syndrome) is a life-threatening presentation of antiphospholipid syndrome which manifests as intravascular thrombosis, leading to rapid onset of symptoms and involvement of multiple organ systems. We present a case of a 28-year-old woman with a history of polyglandular autoimmune syndrome, systemic lupus erythematosus, provoked bilateral deep vein thrombosis in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection 2 years prior, and hypothyroidism who presents with a cardiac arrest in the setting of an acute ST-elevation myocardial infarction with thromboembolic occlusion of two coronary arteries simultaneously in the setting of noncompliance with anticoagulation for the past 1 week. Her presentation was further complicated by acute hypoxic respiratory failure due to diffuse alveolar hemorrhage during the hospital course with progressive multiorgan failure and eventual death. Catastrophic antiphospholipid is associated with high morbidity and mortality, thus a timely diagnosis and multidisciplinary approach to management is needed for evaluation and management.https://doi.org/10.1177/2050313X231220803 |
| spellingShingle | Seyed M Nahidi Yash Garg Devi S Mahadeo Manjari Sharma Cesar Acosta Karthik Seetharam Mukosolu F Obi Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report SAGE Open Medical Case Reports |
| title | Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report |
| title_full | Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report |
| title_fullStr | Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report |
| title_full_unstemmed | Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report |
| title_short | Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report |
| title_sort | cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of covid infection and polyglandular disorder case report |
| url | https://doi.org/10.1177/2050313X231220803 |
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