Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area
Background: Making a clinical and histological distinction between condyloma and seborrheic keratosis in the genitofemoral area can be difficult. This study aimed to find reliable histological and immunohistological criteria to diagnose these entities. Methods: We retrospectively studied genitofemor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-06-01
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| Series: | Dermatologica Sinica |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1027811712000936 |
| _version_ | 1828761645558530048 |
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| author | Yu-Hung Wu Pa-Fan Hsiao Chi-Kuan Chen |
| author_facet | Yu-Hung Wu Pa-Fan Hsiao Chi-Kuan Chen |
| author_sort | Yu-Hung Wu |
| collection | DOAJ |
| description | Background: Making a clinical and histological distinction between condyloma and seborrheic keratosis in the genitofemoral area can be difficult. This study aimed to find reliable histological and immunohistological criteria to diagnose these entities.
Methods: We retrospectively studied genitofemoral skin biopsy specimens obtained between January 2004 and December 2007 that had been diagnosed as showing condyloma or seborrheic keratosis. The histological findings were assessed and immunohistochemical stains were performed for human papillomavirus, Ki-67, and p21. DNA was extracted from paraffin sections and amplified by polymerase chain reaction to detect the presence and type of human papillomavirus.
Results: DNA extraction was successfully performed for 58 lesions. The final diagnoses were condyloma in 41 and seborrheic keratosis in 17. The diagnosis of condyloma rather than seborrheic keratosis was likely in the presence of broad, evenly distributed reticulated acanthosis (p<0.0001), koilocytosis (p<0.001), a fascicular arrangement of keratinocytes (p<0.01), and an absence of horn cysts (p<0.01). Immunohistochemical staining supported the diagnosis of condyloma when positive for human papillomavirus (p<0.0001), Ki-67 (p<0.0001), and p21 (p<0.0001).
Conclusion: A combination of histological and immunohistochemical findings is useful to distinguish condyloma from seborrheic keratosis in the genitofemoral area. |
| first_indexed | 2024-12-11T01:32:20Z |
| format | Article |
| id | doaj.art-27c82763c76d4c2db50aca7561981c8d |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-11T01:32:20Z |
| publishDate | 2013-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-27c82763c76d4c2db50aca7561981c8d2022-12-22T01:25:19ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172013-06-01312545810.1016/j.dsi.2012.09.008Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral areaYu-Hung Wu0Pa-Fan Hsiao1Chi-Kuan Chen2Mackay Medical College, New Taipei City, TaiwanMackay Medical College, New Taipei City, TaiwanMackay Medical College, New Taipei City, TaiwanBackground: Making a clinical and histological distinction between condyloma and seborrheic keratosis in the genitofemoral area can be difficult. This study aimed to find reliable histological and immunohistological criteria to diagnose these entities. Methods: We retrospectively studied genitofemoral skin biopsy specimens obtained between January 2004 and December 2007 that had been diagnosed as showing condyloma or seborrheic keratosis. The histological findings were assessed and immunohistochemical stains were performed for human papillomavirus, Ki-67, and p21. DNA was extracted from paraffin sections and amplified by polymerase chain reaction to detect the presence and type of human papillomavirus. Results: DNA extraction was successfully performed for 58 lesions. The final diagnoses were condyloma in 41 and seborrheic keratosis in 17. The diagnosis of condyloma rather than seborrheic keratosis was likely in the presence of broad, evenly distributed reticulated acanthosis (p<0.0001), koilocytosis (p<0.001), a fascicular arrangement of keratinocytes (p<0.01), and an absence of horn cysts (p<0.01). Immunohistochemical staining supported the diagnosis of condyloma when positive for human papillomavirus (p<0.0001), Ki-67 (p<0.0001), and p21 (p<0.0001). Conclusion: A combination of histological and immunohistochemical findings is useful to distinguish condyloma from seborrheic keratosis in the genitofemoral area.http://www.sciencedirect.com/science/article/pii/S1027811712000936condylomagenitofemoral areahuman papillomavirusKi-67p21seborrheic keratosis |
| spellingShingle | Yu-Hung Wu Pa-Fan Hsiao Chi-Kuan Chen Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area Dermatologica Sinica condyloma genitofemoral area human papillomavirus Ki-67 p21 seborrheic keratosis |
| title | Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area |
| title_full | Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area |
| title_fullStr | Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area |
| title_full_unstemmed | Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area |
| title_short | Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area |
| title_sort | histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area |
| topic | condyloma genitofemoral area human papillomavirus Ki-67 p21 seborrheic keratosis |
| url | http://www.sciencedirect.com/science/article/pii/S1027811712000936 |
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