Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
Pati Aji Achdiat, Kristina Makarti Adriyani, Argani Gracias Pospos, Rasmia Rowawi, Reti Hindritiani, Oki Suwarsa, Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Pati Aji AchdiatDep...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-11-01
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| Series: | HIV/AIDS: Research and Palliative Care |
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| Online Access: | https://www.dovepress.com/two-cases-of-giant-molluscum-contagiosum-on-the-eyelids-of-hiv-patient-peer-reviewed-fulltext-article-HIV |
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| author | Achdiat PA Adriyani KM Pospos AG Rowawi R Hindritiani R Suwarsa O Gunawan H |
| author_facet | Achdiat PA Adriyani KM Pospos AG Rowawi R Hindritiani R Suwarsa O Gunawan H |
| author_sort | Achdiat PA |
| collection | DOAJ |
| description | Pati Aji Achdiat, Kristina Makarti Adriyani, Argani Gracias Pospos, Rasmia Rowawi, Reti Hindritiani, Oki Suwarsa, Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Pati Aji AchdiatDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, IndonesiaEmail pati.aji.achdiat@unpad.ac.idAbstract: Molluscum contagiosum (MC) is an infectious disease caused by the MC virus. In human immunodeficiency virus (HIV) patients, MC has an atypical predilection and prominence, sometimes measuring more than 1 cm in diameter, known as giant MC. Giant MC lesions on the eyelids are rare. There is no standardized therapy for eyelids MC in HIV patients. Antiretroviral (ARV) administration is recommended as the primary treatment for MC in HIV patients along with other treatment modalities, such as potassium hydroxide (KOH). The 20% KOH solution is a keratolytic agent with good efficacy as MC therapy. Two cases of giant MC on the eyelids of stage 2 HIV patients with respective CD4+ of 31 cells/μL and 46 cells/μL were reported. The lesions consisted of multiple confluent papules with central umbilication, and Tzanck smear revealed Henderson–Patterson bodies. Both patients were treated with ARV and self-applied 20% KOH solution once daily. The lesions improved after four weeks of therapy in both patients with most of the lesions diminished. The successful treatment with 20% KOH solution for giant MC on the eyelids of HIV patients observed in the current study provides evidence that treatment with this solution yielded prompt results, is non-toxic, and can be self-applied.Keywords: eyelids, giant molluscum contagiosum, HIV, potassium hydroxide solution, KOH, human immunodeficiency virus |
| first_indexed | 2024-12-18T23:49:30Z |
| format | Article |
| id | doaj.art-27c8648b16164def8956156a98fa424d |
| institution | Directory Open Access Journal |
| issn | 1179-1373 |
| language | English |
| last_indexed | 2024-12-18T23:49:30Z |
| publishDate | 2021-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | HIV/AIDS: Research and Palliative Care |
| spelling | doaj.art-27c8648b16164def8956156a98fa424d2022-12-21T20:47:02ZengDove Medical PressHIV/AIDS: Research and Palliative Care1179-13732021-11-01Volume 1399399770763Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide SolutionAchdiat PAAdriyani KMPospos AGRowawi RHindritiani RSuwarsa OGunawan HPati Aji Achdiat, Kristina Makarti Adriyani, Argani Gracias Pospos, Rasmia Rowawi, Reti Hindritiani, Oki Suwarsa, Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Pati Aji AchdiatDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, IndonesiaEmail pati.aji.achdiat@unpad.ac.idAbstract: Molluscum contagiosum (MC) is an infectious disease caused by the MC virus. In human immunodeficiency virus (HIV) patients, MC has an atypical predilection and prominence, sometimes measuring more than 1 cm in diameter, known as giant MC. Giant MC lesions on the eyelids are rare. There is no standardized therapy for eyelids MC in HIV patients. Antiretroviral (ARV) administration is recommended as the primary treatment for MC in HIV patients along with other treatment modalities, such as potassium hydroxide (KOH). The 20% KOH solution is a keratolytic agent with good efficacy as MC therapy. Two cases of giant MC on the eyelids of stage 2 HIV patients with respective CD4+ of 31 cells/μL and 46 cells/μL were reported. The lesions consisted of multiple confluent papules with central umbilication, and Tzanck smear revealed Henderson–Patterson bodies. Both patients were treated with ARV and self-applied 20% KOH solution once daily. The lesions improved after four weeks of therapy in both patients with most of the lesions diminished. The successful treatment with 20% KOH solution for giant MC on the eyelids of HIV patients observed in the current study provides evidence that treatment with this solution yielded prompt results, is non-toxic, and can be self-applied.Keywords: eyelids, giant molluscum contagiosum, HIV, potassium hydroxide solution, KOH, human immunodeficiency virushttps://www.dovepress.com/two-cases-of-giant-molluscum-contagiosum-on-the-eyelids-of-hiv-patient-peer-reviewed-fulltext-article-HIVeyelidsgiant molluscum contagiosumhivpotassium hydroxide solution |
| spellingShingle | Achdiat PA Adriyani KM Pospos AG Rowawi R Hindritiani R Suwarsa O Gunawan H Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution HIV/AIDS: Research and Palliative Care eyelids giant molluscum contagiosum hiv potassium hydroxide solution |
| title | Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution |
| title_full | Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution |
| title_fullStr | Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution |
| title_full_unstemmed | Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution |
| title_short | Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution |
| title_sort | two cases of giant molluscum contagiosum on the eyelids of hiv patients successfully treated with adjuvant self applied topical 20 potassium hydroxide solution |
| topic | eyelids giant molluscum contagiosum hiv potassium hydroxide solution |
| url | https://www.dovepress.com/two-cases-of-giant-molluscum-contagiosum-on-the-eyelids-of-hiv-patient-peer-reviewed-fulltext-article-HIV |
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