Ammonia Scavenger Restores Liver and Muscle Injury in a Mouse Model of Non-alcoholic Steatohepatitis With Sarcopenic Obesity

Ammonia Scavenger Restores Liver and Muscle Injury in a Mouse Model of Non-alcoholic Steatohepatitis With Sarcopenic Obesity

Recent studies have revealed that sarcopenia is closely associated with obesity and non-alcoholic steatohepatitis (NASH). However, few attempted to explore the cause-and-effect relationship between sarcopenic obesity and NASH. In this study, we investigated muscular alterations in a rodent NASH mode...

Full description

Bibliographic Details
Main Authors:	Zi-Xuan Wang, Meng-Yu Wang, Rui-Xu Yang, Ze-Hua Zhao, Feng-Zhi Xin, Yu Li, Tian-Yi Ren, Jian-Gao Fan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Nutrition
Subjects:	sarcopenia obesity ammonia L-ornithine L-aspartate steatohepatitis
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2022.808497/full

Similar Items

Impact of L-ornithine L-aspartate on non-alcoholic steatohepatitis-associated hyperammonemia and muscle alterations
by: Camille Pichon, et al.
Published: (2022-11-01)

Asthenia and fatigue in hyperammonemia: etiopathogenesis and methods of correction
by: E. Yu. Plotnikova, et al.
Published: (2022-01-01)

Efficacy of oral L-ornithine L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy
by: Claudia Isabel Blanco Vela, et al.
Published: (2011-01-01)

POSSIBILITIES TO USE L-ORNITINE-L-ASPARTATE IN THERAPY OF NON-ALCOHOL FATTY LIVER DISEASE PATIENTS
by: L. A. Teterina, et al.
Published: (2017-11-01)

Hepatic encephalopathy: features of pharmacotherapy
by: A. V. Polukhina, et al.
Published: (2018-04-01)

A Simple Algorithm for Semiquantitative Analysis of Scored Histology Data in the R Environment, on the Example of Murine Non-Alcoholic Steatohepatitis Pharmacotherapy
by: Veronika A. Prikhodko, et al.
Published: (2022-12-01)

Visión actual sobre el diagnóstico y los cuidados integrales en la encefalopatía hepática
by: F. Higuera-de-la-Tijera, et al.
Published: (2023-04-01)

Efficacy of L-Ornithine L-Aspartate in Recovery of Patients Suffering from Acute Viral Hepatitis
by: Ebtihal Bilal, et al.
Published: (2023-06-01)

Effect of rifaximin, probiotics, and l-ornithine l-aspartate on minimal hepatic encephalopathy: A randomized controlled trial
by: Kapil Sharma, et al.
Published: (2014-01-01)

Oral Intake of L-Ornithine-L-Aspartate Is Associated with Distinct Microbiome and Metabolome Changes in Cirrhosis
by: Angela Horvath, et al.
Published: (2022-02-01)

Diagnostic and Prognostic Value of Hyperammonemia in Patients with Liver Cirrhosis, Hepatic Encephalopathy, and Sarcopenia (Experts’ Agreement)
by: M. Yu. Nadinskaia, et al.
Published: (2024-03-01)

Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease
by: Roger F. Butterworth, et al.
Published: (2019-03-01)

Ornithine Aspartate and Vitamin-E Combination Has Beneficial Effects on Cardiovascular Risk Factors in an Animal Model of Nonalcoholic Fatty Liver Disease in Rats
by: Laura Bainy Rodrigues de Freitas, et al.
Published: (2022-11-01)

Hyperammonaemia in patients with chronic obstructive pulmonary disease and obesity: association mechanisms, detection rate and correction
by: S. A. Kozhevnikova, et al.
Published: (2020-02-01)

Possibilities of therapeutic correction of hyperammonemia and minimal hepatic encephalopathy in patients with chronic hepatitis C at the pre-cirrhotic stage
by: A O Buyeverov, et al.
Published: (2019-02-01)

Ammonia as a neuro- and hepatotoxin: clinical aspects
by: A. O. Bueverov
Published: (2015-12-01)

Bipolar Membrane Electrodialysis for Direct Conversion of L-Ornithine Monohydrochloride to L-Ornithine
by: Jinfeng He, et al.
Published: (2023-08-01)

Hepatological Aspects of Metabolic Syndrome and Possibilities of Pathogenetic Treatment
by: V.V. Cherniavskyi, et al.
Published: (2014-11-01)

Different types of hyperammonemia in clinical practice
by: E. Yu. Plotnikova, et al.
Published: (2018-10-01)

LATENT HEPATIC ENCEPHALOPATHY IN PATIENTS WITH MINIMUM HEPATIC FIBROSIS
by: P. O. BOGOMOLOV, et al.
Published: (2016-12-01)

Role of aspartate ammonia-lyase in Pasteurella multocida
by: Zui Wang, et al.
Published: (2020-12-01)

Myosteatosis rather than sarcopenia associates with non‐alcoholic steatohepatitis in non‐alcoholic fatty liver disease preclinical models
by: Maxime Nachit, et al.
Published: (2021-02-01)

Biochemical responses of two Erythrinidae fish to environmental ammonia
by: G. Moraes, et al.

Comparison of the Ornithine Carbamyltransferase with Aspartate Aminotransferase and Alanine Aminotransferase in patients with liver diseases
by: HR.Joshaghani, et al.
Published: (2002-09-01)

Optimization of ʟ-ornithine production in recombinant Corynebacterium glutamicum S9114 by cg3035 overexpression and manipulating the central metabolic pathway
by: Bin Zhang, et al.
Published: (2018-06-01)

The efficacy of L-carnitine in patients with nonalcoholic steatohepatitis and concomitant obesity
by: Natalia Zakharova, et al.
Published: (2023-07-01)

Metabolic Engineering of Bacillus amyloliquefaciens to Efficiently Synthesize L-Ornithine From Inulin
by: Yifan Zhu, et al.
Published: (2022-06-01)

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks
by: Vishwajit S. Chowdhury, et al.
Published: (2015-10-01)

Hyperammonemia of unknown cause in a young postpartum woman: a case report
by: Sadaf Hanif, et al.
Published: (2022-03-01)

Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis
by: Rui Yu, et al.
Published: (2018-04-01)

Sarcopenia: Ammonia metabolism and hepatic encephalopathy
by: Ankur Jindal, et al.
Published: (2019-09-01)

Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis
by: Yi-wen Shi, et al.
Published: (2023-02-01)

L-Selectin/CD62L Is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men
by: Hannah K. Drescher, et al.
Published: (2020-04-01)

Systematic pathway engineering of Corynebacterium glutamicum S9114 for l-ornithine production
by: Bin Zhang, et al.
Published: (2017-09-01)

Ammonia Induces a Myostatin-Mediated Atrophy in Mammalian Myotubes, but Induces Hypertrophy in Avian Myotubes
by: Rachel A. Stern, et al.
Published: (2019-12-01)

Chemotherapy-associated steatohepatitis
by: Lucy Meunier, et al.
Published: (2020-11-01)

Simulation and Study of PEMFC System Directly Fueled by Ammonia Decomposition Gas
by: Jian Feng Zhao, et al.
Published: (2022-03-01)

L-Ornithine-L-Aspartate and Intermittent Renal Replacement Therapy in Fulminant Hepatitis A
by: Nourhane Obeid, et al.
Published: (2023-03-01)

Role of Brain Biomarkers S-100-Beta and Neuron-Specific Enolase for Detection and Follow-Up of Hepatic Encephalopathy in Cirrhosis before, during and after Treatment with L-Ornithine-L-Aspartate
by: Hendrik Strebel, et al.
Published: (2020-04-01)

Insight into the Substrate Specificity of <i>Lactobacillus paracasei</i> Aspartate Ammonia-Lyase
by: Yi-Hao Huang, et al.
Published: (2023-01-01)