A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

Cytokine-mediated activation of host immunity is central to the control of pathogens. Interferon-gamma (IFNγ) is a key cytokine in protective immunity that induces major histocompatibility complex class II molecules (MHCII) to amplify CD4+ T cell activation and effector function. Despite its central...

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Bibliographic Details
Main Authors: Michael C Kiritsy, Laurisa M Ankley, Justin Trombley, Gabrielle P Huizinga, Audrey E Lord, Pontus Orning, Roland Elling, Katherine A Fitzgerald, Andrew J Olive
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
IFN-gamma
MHCII expression
CD4+ T cell activation
macrophages
Online Access:https://elifesciences.org/articles/65110

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