SP600125, a JNK-Specific Inhibitor, Regulates in vitro Auricular Cartilage Regeneration by Promoting Cell Proliferation and Inhibiting Extracellular Matrix Metabolism

SP600125, a JNK-Specific Inhibitor, Regulates in vitro Auricular Cartilage Regeneration by Promoting Cell Proliferation and Inhibiting Extracellular Matrix Metabolism

In vitro construction is a major trend involved in cartilage regeneration and repair. Satisfactory in vitro cartilage regeneration depends on a suitable culture system. Current chondrogenic culture systems with a high content of transforming growth factor beta-1 effectively promote cartilaginous ext...

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Bibliographic Details
Main Authors: Peiling Zhang, Yanqun Liu, Litao Jia, Zheng Ci, Wei Zhang, Yu Liu, Jie Chen, Yilin Cao, Guangdong Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
JNK inhibitors
SP600125
cell proliferation
extracellular matrix
in vitro
cartilage regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.630678/full

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