Enhancing co-translational folding of heterologous protein by deleting non-essential ribosomal proteins in Pichia pastoris

Enhancing co-translational folding of heterologous protein by deleting non-essential ribosomal proteins in Pichia pastoris

Abstract Background Translational regulation played an important role in the correct folding of heterologous proteins to form bioactive conformations during biogenesis. Translational pausing coordinates protein translation and co-translational folding. Decelerating translation elongation speed has b...

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Bibliographic Details
Main Authors: Xihao Liao, Jing Zhao, Shuli Liang, Jingjie Jin, Cheng Li, Ruiming Xiao, Lu Li, Meijin Guo, Gong Zhang, Ying Lin
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Biotechnology for Biofuels
Subjects:
Heterologous protein
Pichia pastoris
Ribosomal protein
Translation
Co-translational folding
Online Access:http://link.springer.com/article/10.1186/s13068-019-1377-z

Internet

http://link.springer.com/article/10.1186/s13068-019-1377-z

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