Chronic Liver Diseases and COVID-19: Database of General Hospital

Patients with chronic liver diseases (CLD) are at high risk of infection and severe COVID-19 (Corona Virus Disease).Aim: to create a database of patients with CLD, including an analysis of the frequency of detection of SARS-CoV-2 markers, the causes of hospitalization, an assessment of 30-day mortal...

Full description

Bibliographic Details
Main Authors: E. Yu. Sitnikova, L. Yu. Ilchenko, I. G. Fedorov, I. G. Nikitin
Format: Article
Language:Russian
Published: SINAPS LLC 2023-01-01
Series:Архивъ внутренней медицины
Subjects:
Online Access:https://www.medarhive.ru/jour/article/view/1562
_version_ 1797883694446280704
author E. Yu. Sitnikova
L. Yu. Ilchenko
I. G. Fedorov
I. G. Nikitin
author_facet E. Yu. Sitnikova
L. Yu. Ilchenko
I. G. Fedorov
I. G. Nikitin
author_sort E. Yu. Sitnikova
collection DOAJ
description Patients with chronic liver diseases (CLD) are at high risk of infection and severe COVID-19 (Corona Virus Disease).Aim: to create a database of patients with CLD, including an analysis of the frequency of detection of SARS-CoV-2 markers, the causes of hospitalization, an assessment of 30-day mortality in the presence of COVID-19 markers and in the absence of infection.Materials and methods. A one-time retrospective observational comparative study was conducted, the result of which was the creation of a database. 693 electronic case hystories of patients with CLD of various etiologies hospitalized in the V.M. Buyanov State Clinical Hospital for the period 01.04.2020–01.10.2021 were analyzed. Th e analysis included the following parameters: gender, age, etiology of the disease, reasons for hospitalization, the presence of ribonucleic acid (RNA) SARS-CoV-2 in a smear of the nasal mucosa and oropharynx, antibodies to SARS-CoV-2 immunoglobulins of classes M, G (IgM, IgG), the outcome of the disease (30-day mortality).Results. Markers of past new coronavirus infection (IgG) were detected in 268 (38,7 %), SARS-CoV-2 RNA was detected in 67 (9,7 %). Th e analysis of the causes of hospitalization revealed the predominance of edematous ascitic syndrome (64,5 %), an increase in hepatic encephalopathy (31,6 %) and an increase in the number of cases of portal vein thrombosis (PVT) (8,9 %). When assessing the 30-day mortality, signifi cant diff erences were found in patients with Alcohol-related liver disease (ARLD), chronic viral hepatitis in the presence of COVID-19 markers and in cases of their absence.Conclusion. SARSCoV-2 markers were found in 335 (48,3 %) of patients with CLD. Th e main reason for hospitalization is the appearance /increase of edematous ascitic syndrome, including due to PVT. 30-day mortality in the postcovid period is signifi cantly higher (р = 0,0246) in ARLD compared with patients without COVID-19 (218 (34,9 %) и 300 (25,3 %), respectively, р = 0,0246).
first_indexed 2024-04-10T03:55:48Z
format Article
id doaj.art-27cdf1796ca544759e86bbecb68e7b4c
institution Directory Open Access Journal
issn 2226-6704
2411-6564
language Russian
last_indexed 2024-04-10T03:55:48Z
publishDate 2023-01-01
publisher SINAPS LLC
record_format Article
series Архивъ внутренней медицины
spelling doaj.art-27cdf1796ca544759e86bbecb68e7b4c2023-03-13T07:12:11ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642023-01-01131576410.20514/2226-6704-2023-13-1-57-64930Chronic Liver Diseases and COVID-19: Database of General HospitalE. Yu. Sitnikova0L. Yu. Ilchenko1I. G. Fedorov2I. G. Nikitin3Кафедра госпитальной терапии имени академика Г.И. Сторожакова лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава РоссииКафедра госпитальной терапии имени академика Г.И. Сторожакова лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России; Федеральное государственное бюджетное научное учреждение «Федеральный научный центр исследований и разработки иммунобиологических препаратов им. М.П. Чумакова РАНКафедра госпитальной терапии имени академика Г.И. Сторожакова лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России; Государственное бюджетное учреждение здравоохранения «Городская клиническая больница имени В.М. Буянова» Департамента здравоохранения города МосквыКафедра госпитальной терапии имени академика Г.И. Сторожакова лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава РоссииPatients with chronic liver diseases (CLD) are at high risk of infection and severe COVID-19 (Corona Virus Disease).Aim: to create a database of patients with CLD, including an analysis of the frequency of detection of SARS-CoV-2 markers, the causes of hospitalization, an assessment of 30-day mortality in the presence of COVID-19 markers and in the absence of infection.Materials and methods. A one-time retrospective observational comparative study was conducted, the result of which was the creation of a database. 693 electronic case hystories of patients with CLD of various etiologies hospitalized in the V.M. Buyanov State Clinical Hospital for the period 01.04.2020–01.10.2021 were analyzed. Th e analysis included the following parameters: gender, age, etiology of the disease, reasons for hospitalization, the presence of ribonucleic acid (RNA) SARS-CoV-2 in a smear of the nasal mucosa and oropharynx, antibodies to SARS-CoV-2 immunoglobulins of classes M, G (IgM, IgG), the outcome of the disease (30-day mortality).Results. Markers of past new coronavirus infection (IgG) were detected in 268 (38,7 %), SARS-CoV-2 RNA was detected in 67 (9,7 %). Th e analysis of the causes of hospitalization revealed the predominance of edematous ascitic syndrome (64,5 %), an increase in hepatic encephalopathy (31,6 %) and an increase in the number of cases of portal vein thrombosis (PVT) (8,9 %). When assessing the 30-day mortality, signifi cant diff erences were found in patients with Alcohol-related liver disease (ARLD), chronic viral hepatitis in the presence of COVID-19 markers and in cases of their absence.Conclusion. SARSCoV-2 markers were found in 335 (48,3 %) of patients with CLD. Th e main reason for hospitalization is the appearance /increase of edematous ascitic syndrome, including due to PVT. 30-day mortality in the postcovid period is signifi cantly higher (р = 0,0246) in ARLD compared with patients without COVID-19 (218 (34,9 %) и 300 (25,3 %), respectively, р = 0,0246).https://www.medarhive.ru/jour/article/view/1562covid-19хронические заболевания печенибаза данныхлетальностьалкогольная болезнь печени
spellingShingle E. Yu. Sitnikova
L. Yu. Ilchenko
I. G. Fedorov
I. G. Nikitin
Chronic Liver Diseases and COVID-19: Database of General Hospital
Архивъ внутренней медицины
covid-19
хронические заболевания печени
база данных
летальность
алкогольная болезнь печени
title Chronic Liver Diseases and COVID-19: Database of General Hospital
title_full Chronic Liver Diseases and COVID-19: Database of General Hospital
title_fullStr Chronic Liver Diseases and COVID-19: Database of General Hospital
title_full_unstemmed Chronic Liver Diseases and COVID-19: Database of General Hospital
title_short Chronic Liver Diseases and COVID-19: Database of General Hospital
title_sort chronic liver diseases and covid 19 database of general hospital
topic covid-19
хронические заболевания печени
база данных
летальность
алкогольная болезнь печени
url https://www.medarhive.ru/jour/article/view/1562
work_keys_str_mv AT eyusitnikova chronicliverdiseasesandcovid19databaseofgeneralhospital
AT lyuilchenko chronicliverdiseasesandcovid19databaseofgeneralhospital
AT igfedorov chronicliverdiseasesandcovid19databaseofgeneralhospital
AT ignikitin chronicliverdiseasesandcovid19databaseofgeneralhospital