NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effects. They comprise a heterogeneous populatio...

Full description

Bibliographic Details
Main Authors:	Motaz M. Fadul, Claire J. Garwood, Rachel Waller, Navonna Garrett, Paul R. Heath, Fiona E Matthews, Carol Brayne, Stephen B. Wharton, Julie E. Simpson
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	International Journal of Molecular Sciences
Subjects:	n-myc downstream regulated gene 2 (ndrg2) astrocyte ageing brain neurofibrillary tangles
Online Access:	https://www.mdpi.com/1422-0067/21/1/340

Similar Items

Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter
by: Daniel Rusiecki, et al.
Published: (2016-06-01)

Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors
by: Florencia A. Monge, et al.
Published: (2023-01-01)

Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
by: Gabriel A. Marx, et al.
Published: (2022-10-01)

Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles
by: Juan C. Vizcarra, et al.
Published: (2023-12-01)

Beyond Amyloid: A Machine Learning-Driven Approach Reveals Properties of Potent GSK-3β Inhibitors Targeting Neurofibrillary Tangles
by: Martin Nwadiugwu, et al.
Published: (2024-02-01)

NDRG1 Expression Is an Independent Prognostic Factor in Inflammatory Breast Cancer
by: Emilly S. Villodre, et al.
Published: (2020-12-01)

NDRG2 gene expression pattern in ovarian cancer and its specific roles in inhibiting cancer cell proliferation and suppressing cancer cell apoptosis
by: Fenhong Kang, et al.
Published: (2020-04-01)

Clinical Diagnostic and Prognostic Potential of NDRG1 and NDRG2 in Hepatocellular Carcinoma Patients
by: Shaohua Xu, et al.
Published: (2022-06-01)

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
by: Clara Muñoz-Castro, et al.
Published: (2022-02-01)

mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma
by: Anisha Valluri, et al.
Published: (2023-05-01)

Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen–glucose deprivation conditions
by: Jinying Xu, et al.
Published: (2022-12-01)

NDRG2 inhibition facilitates angiogenesis of hepatocellular carcinoma
by: Wang Jianlong, et al.
Published: (2021-05-01)

NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary
by: Akemi Nishigaki, et al.
Published: (2022-01-01)

NDRG2 regulates the formation of reactive astrocyte-derived progenitor cells via Notch signaling pathway after brain traumatic injury in rats
by: Qinjun Zhang, et al.
Published: (2023-04-01)

Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches
by: Ayomide Victor Atoki, et al.
Published: (2023-09-01)

N-myc Downstream-Regulated Gene 2 (NDRG2) Function as a Positive Regulator of Apoptosis: A New Insight into NDRG2 as a Tumor Suppressor
by: Gayeon Kim, et al.
Published: (2021-10-01)

Okadaic acid induces damage of human neuroblastoma cell line SH-SY5Y
by: LU Ya-lan, ZHOU Li, HAN Yun-lin, WANG Ke-wei, QIN Chuan
Published: (2022-06-01)

Alzheimer’s disease: A Threat to mankind
by: Poorti Pandey, et al.
Published: (2011-12-01)

Synergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP Cells
by: Alizadeh Zarei M., et al.
Published: (2017-09-01)

Alzheimer’s Disease and Tau Self-Assembly: In the Search of the Missing Link
by: Andrea González, et al.
Published: (2022-04-01)

Body Fluid Biomarkers for Alzheimer’s Disease—An Up-To-Date Overview
by: Adrian Florian Bălașa, et al.
Published: (2020-10-01)

Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer’s Disease
by: Carlos M. Hernandez, et al.
Published: (2023-05-01)

Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease
by: Minghui Wang, et al.
Published: (2023-03-01)

NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide – But not palmitate‐induced toxicity
by: Kimberley J. Anderson, et al.
Published: (2015-01-01)

The Function of N-Myc Downstream-Regulated Gene 2 (NDRG2) as a Negative Regulator in Tumor Cell Metastasis
by: Ki Won Lee, et al.
Published: (2022-08-01)

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
by: Neha Basheer, et al.
Published: (2024-04-01)

Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer’s disease
by: Julian D. Dallmeier, et al.
Published: (2024-02-01)

A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases
by: Selma M. Soyal, et al.
Published: (2020-08-01)

Advances on Therapeutic Strategies for Alzheimer’s Disease: From Medicinal Plant to Nanotechnology
by: Nasser A. Hassan, et al.
Published: (2022-07-01)

How Many Alzheimer–Perusini’s Atypical Forms Do We Still Have to Discover?
by: Luigi Donato, et al.
Published: (2023-07-01)

The Sensitivity of Tau Tracers for the Discrimination of Alzheimer’s Disease Patients and Healthy Controls by PET
by: Zohreh Mohammadi, et al.
Published: (2023-02-01)

Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model
by: Joshua T. Emmerson, et al.
Published: (2023-08-01)

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity
by: Taha F. S. Ali, et al.
Published: (2022-03-01)

Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunctionResearch in context
by: Tao Jiang, et al.
Published: (2023-07-01)

A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas
by: Yukiko Nakahara, et al.
Published: (2022-04-01)

Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET
by: Joanna L. Shuping, et al.
Published: (2023-01-01)

NDRG1 in Cancer: A Suppressor, Promoter, or Both?
by: Vaibhavi Joshi, et al.
Published: (2022-11-01)

The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity
by: Jason Chekmarev, et al.
Published: (2021-09-01)

Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample
by: Regina Silva Paradela, et al.
Published: (2023-12-01)

Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence
by: Ali Azargoonjahromi, et al.
Published: (2024-03-01)