Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess
Abstract Backgrounds Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused...
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05390-z |
| _version_ | 1811333380907728896 |
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| author | Yue Wang Xue Wang Yu Di |
| author_facet | Yue Wang Xue Wang Yu Di |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Abstract Backgrounds Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused by liver abscess. Methods Between April 2014 and April 2019, the clinical data of 16 patients (19 eyes) with endophthalmitis associated with liver abscess who underwent surgery at Shengjing Hospital were retrospectively analyzed. Furthermore, we evaluated the final visual outcomes in the patients to determine the efficacy of surgery. Results Fifteen patients (18 eyes) underwent intravitreal injection followed by vitrectomy after admission. One patient (1 eye) only underwent intravitreal injection. Of the 16 patients, 3 patients (3 eyes) had recurrent intraocular inflammation and eventually underwent evisceration. Systemic antibiotics were administered for all patients based on the results of vitreous humor culture, blood culture, and antibiotic susceptibility tests. Outpatient follow-ups were performed until the patients were stable (6 months). Of the 19 eyes, 1 eye (5%) had visual acuity restored to 20/200, 6 eyes (31%) had visual acuity restored to counting fingers (CF), 2 eyes (11%) had visual acuity restored to hand motion (HM), 4 eyes (22%) showed only light perception (LP), and the remaining 6 eyes (31%) showed no light perception (NLP). Drug susceptibility tests suggested that the carbapenems exhibited significant effects in the inflammatory reaction. Conclusion Endogenous endophthalmitis caused by liver abscess is a very serious condition, and the final visual outcome is poor. Timely surgical intervention combined with antibiotic treatment is essential, and the primary disease must be treated to control disease progression at the earliest. |
| first_indexed | 2024-04-13T16:50:58Z |
| format | Article |
| id | doaj.art-27ce71b144f145f592d50196dbcd7727 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T16:50:58Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-27ce71b144f145f592d50196dbcd77272022-12-22T02:38:56ZengBMCBMC Infectious Diseases1471-23342020-09-012011710.1186/s12879-020-05390-zSurgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscessYue Wang0Xue Wang1Yu Di2Department of Ophthalmology, Shengjing Hospital of China Medical UniversityDepartment of Ophthalmology, Shengjing Hospital of China Medical UniversityDepartment of Ophthalmology, Shengjing Hospital of China Medical UniversityAbstract Backgrounds Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused by liver abscess. Methods Between April 2014 and April 2019, the clinical data of 16 patients (19 eyes) with endophthalmitis associated with liver abscess who underwent surgery at Shengjing Hospital were retrospectively analyzed. Furthermore, we evaluated the final visual outcomes in the patients to determine the efficacy of surgery. Results Fifteen patients (18 eyes) underwent intravitreal injection followed by vitrectomy after admission. One patient (1 eye) only underwent intravitreal injection. Of the 16 patients, 3 patients (3 eyes) had recurrent intraocular inflammation and eventually underwent evisceration. Systemic antibiotics were administered for all patients based on the results of vitreous humor culture, blood culture, and antibiotic susceptibility tests. Outpatient follow-ups were performed until the patients were stable (6 months). Of the 19 eyes, 1 eye (5%) had visual acuity restored to 20/200, 6 eyes (31%) had visual acuity restored to counting fingers (CF), 2 eyes (11%) had visual acuity restored to hand motion (HM), 4 eyes (22%) showed only light perception (LP), and the remaining 6 eyes (31%) showed no light perception (NLP). Drug susceptibility tests suggested that the carbapenems exhibited significant effects in the inflammatory reaction. Conclusion Endogenous endophthalmitis caused by liver abscess is a very serious condition, and the final visual outcome is poor. Timely surgical intervention combined with antibiotic treatment is essential, and the primary disease must be treated to control disease progression at the earliest.http://link.springer.com/article/10.1186/s12879-020-05390-zEndogenous endophthalmitisKlebsiella pneumoniaeLiver abscessVitrectomyVisual acuity |
| spellingShingle | Yue Wang Xue Wang Yu Di Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess BMC Infectious Diseases Endogenous endophthalmitis Klebsiella pneumoniae Liver abscess Vitrectomy Visual acuity |
| title | Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess |
| title_full | Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess |
| title_fullStr | Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess |
| title_full_unstemmed | Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess |
| title_short | Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess |
| title_sort | surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess |
| topic | Endogenous endophthalmitis Klebsiella pneumoniae Liver abscess Vitrectomy Visual acuity |
| url | http://link.springer.com/article/10.1186/s12879-020-05390-z |
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