Antimycobacterial neolignans isolated from Aristolochia taliscana
Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2010-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000100006 |
| _version_ | 1797712657015373824 |
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| author | Rosalba León-Díaz Mariana Meckes Salvador Said-Fernández Gloria Maria Molina-Salinas Javier Vargas-Villarreal Javier Torres Julieta Luna-Herrera Adelina Jiménez-Arellanes |
| author_facet | Rosalba León-Díaz Mariana Meckes Salvador Said-Fernández Gloria Maria Molina-Salinas Javier Vargas-Villarreal Javier Torres Julieta Luna-Herrera Adelina Jiménez-Arellanes |
| author_sort | Rosalba León-Díaz |
| collection | DOAJ |
| description | Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible; in fact, some patients do not respond to the available drugs. Therefore, there is an urgent need to develop novel anti-TB agents. The aim of the present study was to screen extracts of Aristolochia taliscana, a plant used in traditional Mexican medicine to treat cough and snake bites, for antimycobacterial activity. The hexanic extract of A. taliscana was tested by microdilution alamar blue assay against Mycobacterium strains and bioguided fractionation led to the isolation of the neolignans licarin A, licarin B and eupomatenoid-7, all of which had antimycobacterial activity. Licarin A was the most active compound, with minimum inhibitory concentrations of 3.12-12.5 μg/mL against the following M. tuberculosis strains: H37Rv, four mono-resistant H37Rv variants and 12 clinical MDR isolates, as well as against five non-tuberculous mycobacteria (NTM) strains. In conclusion, licarin A represents a potentially active anti-TB agent to treat MDR M. tuberculosis and NTM strains. |
| first_indexed | 2024-03-12T07:24:58Z |
| format | Article |
| id | doaj.art-27ced9a2866c44fdaa6dcafd19a84ccb |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:24:58Z |
| publishDate | 2010-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-27ced9a2866c44fdaa6dcafd19a84ccb2023-09-02T22:10:55ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-02-011051455110.1590/S0074-02762010000100006Antimycobacterial neolignans isolated from Aristolochia taliscanaRosalba León-DíazMariana MeckesSalvador Said-FernándezGloria Maria Molina-SalinasJavier Vargas-VillarrealJavier TorresJulieta Luna-HerreraAdelina Jiménez-ArellanesTuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible; in fact, some patients do not respond to the available drugs. Therefore, there is an urgent need to develop novel anti-TB agents. The aim of the present study was to screen extracts of Aristolochia taliscana, a plant used in traditional Mexican medicine to treat cough and snake bites, for antimycobacterial activity. The hexanic extract of A. taliscana was tested by microdilution alamar blue assay against Mycobacterium strains and bioguided fractionation led to the isolation of the neolignans licarin A, licarin B and eupomatenoid-7, all of which had antimycobacterial activity. Licarin A was the most active compound, with minimum inhibitory concentrations of 3.12-12.5 μg/mL against the following M. tuberculosis strains: H37Rv, four mono-resistant H37Rv variants and 12 clinical MDR isolates, as well as against five non-tuberculous mycobacteria (NTM) strains. In conclusion, licarin A represents a potentially active anti-TB agent to treat MDR M. tuberculosis and NTM strains.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000100006antimycobacterial neolignansA. taliscanaM. tuberculosis H37RvMDR M. tuberculosisnon-tuberculous mycobacteria |
| spellingShingle | Rosalba León-Díaz Mariana Meckes Salvador Said-Fernández Gloria Maria Molina-Salinas Javier Vargas-Villarreal Javier Torres Julieta Luna-Herrera Adelina Jiménez-Arellanes Antimycobacterial neolignans isolated from Aristolochia taliscana Memorias do Instituto Oswaldo Cruz antimycobacterial neolignans A. taliscana M. tuberculosis H37Rv MDR M. tuberculosis non-tuberculous mycobacteria |
| title | Antimycobacterial neolignans isolated from Aristolochia taliscana |
| title_full | Antimycobacterial neolignans isolated from Aristolochia taliscana |
| title_fullStr | Antimycobacterial neolignans isolated from Aristolochia taliscana |
| title_full_unstemmed | Antimycobacterial neolignans isolated from Aristolochia taliscana |
| title_short | Antimycobacterial neolignans isolated from Aristolochia taliscana |
| title_sort | antimycobacterial neolignans isolated from aristolochia taliscana |
| topic | antimycobacterial neolignans A. taliscana M. tuberculosis H37Rv MDR M. tuberculosis non-tuberculous mycobacteria |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000100006 |
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