Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis

Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis

Pancreatic Ductal adenocarcinoma (PDAC) is an aggressive cancer commonly exhibiting KRAS-activating mutations. Alcohol contributes to the risk of developing PDAC in humans, and murine models have shown alcohol consumption in the context of KRAS mutation in the pancreas promotes the development of PD...

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Bibliographic Details
Main Authors: Emalie J. Clement, Henry C.-H. Law, Fangfang Qiao, Dragana Noe, Jose G. Trevino, Nicholas T. Woods
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
alcohol
pancreatic cancer
Proteomics
KRAS
SERPINE1
Online Access:https://www.mdpi.com/2072-6694/14/8/1968

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