Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression
Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression. Unfortunately, there is no drug currently approved for treatment, and the molecular basis of pathogenesis b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/2/242 |
| _version_ | 1827601885746429952 |
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| author | Ja Hyun Koo Chang Yeob Han |
| author_facet | Ja Hyun Koo Chang Yeob Han |
| author_sort | Ja Hyun Koo |
| collection | DOAJ |
| description | Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression. Unfortunately, there is no drug currently approved for treatment, and the molecular basis of pathogenesis by ER stress remains poorly understood. Classical ER stress pathway molecules have distinct but inter-connected functions and complicated effects at each phase of the disease. Identification of the specific molecular signal mediators of the ER stress-mediated pathogenesis is, therefore, a crucial step in the development of new treatments. These signaling nodes may be specific to the cell type and/or the phase of disease progression. In this review, we highlight the recent advancements in knowledge concerning signaling nodes associated with ER stress and NAFLD progression in various types of liver cells. |
| first_indexed | 2024-03-09T05:06:45Z |
| format | Article |
| id | doaj.art-27d24e5456d34e57aced2d6442fc3542 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T05:06:45Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-27d24e5456d34e57aced2d6442fc35422023-12-03T12:54:00ZengMDPI AGBiomolecules2218-273X2021-02-0111224210.3390/biom11020242Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD ProgressionJa Hyun Koo0Chang Yeob Han1Department of Physiology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, KoreaSchool of Pharmacy and Institute of New Drug Development, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, KoreaExcess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression. Unfortunately, there is no drug currently approved for treatment, and the molecular basis of pathogenesis by ER stress remains poorly understood. Classical ER stress pathway molecules have distinct but inter-connected functions and complicated effects at each phase of the disease. Identification of the specific molecular signal mediators of the ER stress-mediated pathogenesis is, therefore, a crucial step in the development of new treatments. These signaling nodes may be specific to the cell type and/or the phase of disease progression. In this review, we highlight the recent advancements in knowledge concerning signaling nodes associated with ER stress and NAFLD progression in various types of liver cells.https://www.mdpi.com/2218-273X/11/2/242ER stressunfold protein responsenonalcoholic fatty liver diseasehepatocyteshepatic stellate cellsKupffer cells |
| spellingShingle | Ja Hyun Koo Chang Yeob Han Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression Biomolecules ER stress unfold protein response nonalcoholic fatty liver disease hepatocytes hepatic stellate cells Kupffer cells |
| title | Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression |
| title_full | Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression |
| title_fullStr | Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression |
| title_full_unstemmed | Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression |
| title_short | Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression |
| title_sort | signaling nodes associated with endoplasmic reticulum stress during nafld progression |
| topic | ER stress unfold protein response nonalcoholic fatty liver disease hepatocytes hepatic stellate cells Kupffer cells |
| url | https://www.mdpi.com/2218-273X/11/2/242 |
| work_keys_str_mv | AT jahyunkoo signalingnodesassociatedwithendoplasmicreticulumstressduringnafldprogression AT changyeobhan signalingnodesassociatedwithendoplasmicreticulumstressduringnafldprogression |